Streptomyces pneumoniae

As mentioned earlier, a-D-carba-galactopyranose (1) has been found in a fermentation broth of Streptomyces sp. MA-4145, as an antibiotic. The potency of the antibiotic was rather low. A concentration of—125 fig/mh is required in order to produce a standard inhibition zone of 25-mm diameter against Klebsiella pneumoniae MB-1264, using 13-mm assay discs in a disc-plate assay. A sample of the synthetic a-DL-carba-galactopyranose (17) was... 

Flurithromycin (120), a fluorinated erythromycin macrolide, has been isolated from a mutant strain of Streptomyces erythraeus. It shows antibacterial activity against Streptococcus pneumoniae (MIC 0.0015-... 

Thermus aquaticus Thermus thermophilus Thermus filiformis Deinococcus radiodurans Escherichia coli Haemophilus influenzae Streptococus pneumoniae Mycobacterium tuberculosis Mycobacterium laprae Treponema pallidum Chlamydia trachomatis Boriela burgdorferi Helicobacter pyroli Lactococcus lactis Mythelobacterium Rhodothermus obamensis Rickettsia prowazekii Streptomyces coelicolor Bacillus stearothermophilus Synechocystis sp Aquifex aeolicus Apse-1 DNA polymerase T7 DNA polymerase T5 DNA polymerase ... 

Escherichia coll Haemophilus Influenzae Klebsiella pneumonia Provldencla stuartll Streptomyces achromogenes Streptomyces albue Serratia marcescens Streptomyces phaeochromogenes Xanthomonas badiil... 

Klebsiella pneumoniae [22] <13> Mycoplasma capricolum [26] <14> Streptomyces lividans [28] <15> Streptomyces coelicolor [28] <16> Streptomyces griseofuscus [28]... 

Fosfomycin is one of a few natural products containing a carbon-phosphorus (C— P) bond isolated from Streptomyces fradiae, Streptomyces viridochromogenes, and Streptomyces wedmorensis [73]. It was also isolated from Pseudomonas syringae and Pseudomonas viridiflava [74, 75], Fosfomycin is a highly effective antibiotic of low toxicity clinically utilized for the treatment of lower urinary tract infections [76] as well as methicillin-resistant [77] and vancomycin-resistant [78] strains of S. aureus. Moreover, fosfomycin is effective for the treatment of cephalosporin- and penicillin-resistant Streptococcus pneumonia [79] and ciprofloxacin-resistant E. coli [80], The antimicrobial activity of fosfomycin has been ascribed to the inactivation of UDP-GlcAAc-3-O-enolpyruvyltransferase (MurA), an essential enzyme that catalyzes the first committed step in the biosynthesis of peptidoglycan, the main component of the cell wall, by covalent alkylation of an active site cysteine [81]. 

Tetracyclines a group of antibiotics from various Streptomyces spp. T. contain four linearly fused six-membered rin individual T. differ according to the nature of substituents (Fig. and Table). T. inhibit protein biosynthesis by preventing the binding of ami-noacyl-tRNA to ribosomes. Next to the penicillins, T. were one of the most widely used antibiotics, particularly in the treatment of bronchitis, pneumonia, bile duct and urinary infections, plague and cholera. They are also widely employed as additives in animal feed-stuffs. On account of side reactions and increasing resistance of bacteria to T. their use is declining. 

Uses antibiotic and antirickettsial substance produced by Streptomyces venezuelae in eye drops and ointments for systemic use for infections, such as pneumonia, meningitis and infections of the epiglottis (lower throat) as a bactericide against the rot of potatoes and other root vegetables Cross azidamfenicol. ICU A... 

From Streptomyces elgreteus. Only active against Streptococcus pneumoniae. Orange cryst. Sol. MeOH, CHCI3, EtOAc poorly sol. H2O, hexane. X , 225 (e 36300) 266 (e 20000) 287 (e 17800) 434 (c 11200) (MeOH) (Derep). 

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