Streptococcus pyogenes inhibition

Cue D, Southern S, Southern P et al (2000) A non-peptide integrin antagonist can inhibit epithelial cell ingestion of streptococcus pyogenes by blocking a5 31 -fibronectin-Ml protein complexes. Proc Nat Acad Sci 97(6) 2858-2863... 

Thus, at pH 7.3, 9-aminoacridine, which exists at this pH entirely as the cation, will inhibit the growth of Streptococcus pyogenes at a dilution of 1 160000 the... 

Bergey, E. J., and Stinson, M. W. (1988). Heparin-inhibitable basement membrane-binding protein of Streptococcus pyogenes. Infect. Immun. 56,1715-1721. 

Figure 14 Inhibition of Streptococcus pyogenes Glu-AdT by glutamyl-7-boronates.

Mupirocin (Bactroban) inhibits a specific enzyme responsible for tRNA synthesis in susceptible bacteria. This drug is used topically to treat skin infections caused by Staphylococcus aureus or Streptococcus pyogenes. Likewise, mupirocin can be administered by nasal spray to treat local colonization of S. aureus in the nasal mucosa. This idea may be especially helpful in preventing systemic infection in individuals such as health care workers who are exposed to an outbreak of resistant strains of S. aureus. Local/topical administration of this drug is well tolerated, although some irritation of the skin may occur during topical use, and cough and respiratory irritation can occur when mupirocin is administered by nasal spray. 

Biological activity of the macrolide derived from tylosin against Pasteurella multocida and P. haemolytica (in particular) in vitro and P. multicida (in particular) in vivo has been tested on chicks. Remarkable inhibition of these viruses is obtained. It is also found active against Staphylococcus aureus, Streptococcus pyogenes and pneumoniae, Haemophilus influenzae, Mycoplasma gallisepticum, synoviae, hyorhinis and hyopneumoniae 222... 

The aqueous/methanol fraction of the dichloromethane extract of Carthamus lanatus L. exhibited a high rate of antibacterial activity against Staphylococcus aureus and Escherichia coli [35], while crude dichloromethane extracts of the aerial parts and roots of Leontopodium alpinum Cass, exhibited significant growth inhibition of Bacillus subtilis, Escherichia coli. Pseudomonas aeruginosa. Staphylococcus aureus and Streptococcus pyogenes [36]. 

Examples of other antimicrobial coumarins from the Anthemideae tribe also included the coumarin derivatives isolated from the seeds of Centaurea nigra L. [243] and one coumarin isolated from Leontopodium alpinum, which selectively inhibited the growth of Streptococcus pyogenes and Streptococcus pneumoniae [36]. 

Kava has been used traditionally as an antibacterial in the treatment of urinary tract infections (Locher et al., 1995) however, no clinical trials have established that it is truly effective. Kava extracts were not able to inhibit growth of Candida, Pseudomonas, E. coli, Streptococcus pyogenes, or Staphylococcus aureus (Locher et al., 1995). 

Seshachalam, D., Frahm, D. H., Ferraro, F. M. Antimicrob. Agents Chemother. 3 (1), 63 (1973). Cation reversal of inhibition of growth by valinomycin in Streptococcus pyogenes and Clostridium sporogenes... 

Penicillin, in regard to infections with sensitive microbes, appears to have some advantages over the well-known chemical antiseptics. A good sample will inhibit staphylococci, Streptococcus pyogenes and pneumococcus in a dilution of 1 in 800. It is therefore a more powerful inhibitory agent than is carbolic acid and... it is non-irritant and non-toxic. 

Mupirocin is an antibiotic agent that inhibits bacterial protein synthesis. It is indicated in treatment of impetigo caused by Staphylococcus aureus and Streptococcus pyogenes (topical ointment) and treatment of secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm in area). 

Quinupristin/dalfopristin is a streptogramin. Quinupristin inhibits the late phase of protein synthesis dalfopristin inhibits the early phase of protein synthesis. It is indicated in the treatment of serious or life-threatening infections associated with VREF treatment of complicated skin and skin-structure infections caused by Staphylococcus aureus (methicillin-susceptible) or Streptococcus pyogenes. 

Many bacteria are much more sensitive than E. coli to crystal violet. Thus Streptococcus pyogenes is inhibited by a dilution of 1 in 320000 (though not by 1 in 640000) and Staphylococcus aureus is killed by 1 in 2000000. Although these differences may be partly due to differences in sites of loss, there are different values for different species and (in the hosts) for different tissues in the one species. This affords a basis for the selective action of cationic drugs. 

Isol. from faeces of blood group B human infants. Inhibits adhesion of Streptococcus pyogenes to epithelial pharyngeal cells. Patented for use in mouthrinses. Needles +0.5 H2O (Eton aqd. 

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