Starvation metabolic changes

A detailed account of the metabolic changes that occur in starvation and the role they play in ensuring survival, from even a prolonged period of starvation, is presented in Chapter 16. 

Figure 16.11 Pattern of fuel utilisation during prolonged starvation. The major metabolic change during this period is that the rates of ketone body formation and their utilisation by the brain increases, indicated by the increased thickness of lines and arrows. Since less glucose is required by the brain, gluconeogenesis from amino acids is reduced so that protein degradation in muscle is decreased. Note thin line compared to that in Figure 16.9.

Sequence of metabolic changes from intermediate starvation to death... 

Food Intake and Starvation Induce Metabolic Changes... 

Be familiar with the metabolic change in fasting states as compared to starvation. 

In cases of starvation many metabolic changes take place to meet the body s metabolic demands. Which of the following illustrates starvation-triggered changes in intermediary metabolism ... 

Explain the metabolic changes that occur during starvation. What appears to be the principal purpose for the preferential degradation of muscle tissue during starvation ... 

Describe the metabolic changes that occur after one and three days of starvation. Discuss the metabolic adaptations that occur after prolonged starvation note especially the shift in brain fuels and the decreased rate of protein degradation. 

Phospholipid fatty add assays can also indicate metabolic changes in a microbial community. During nutrient deprivation and other environmental stresses, fatty add ratios can shift. Guckert et al. [36] found increases in the transxis ratio of monoenoic 16-carbon tty adds in Vibrio cholerae during nutrient starvation. The protocol used to extract the lipids fix>m environmental samples simultaneously extracts other biochemical indicators of nutritional status in microbial communities, for example, poly-P-hydroxyalkanoates [31]. 

A similar lack of adverse effects of halothane has been found in liver tissue metabolic intermediates in animals fed a high fat diet, or animals starved for 24 hours (Biebuyck and Lund, 1972). Thus, situations in which a high concentration of fatty acids is available to the liver (starvation or exogenous administration), appear to have a protective effect against metabolic changes bought about by halothane. 

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