Stage testing

The critical components should be listed and checked to see that prior usage is within the range of experience. It should be determined if the impellers have been stage tested and whether this performance has been reflected in actual field experience. Prior use history of the blading geometry being proposed should be reviewed. This should include the... 

Panter, G.H., Hutchinson, T.H., and Hurd, K.S. et al. (2006). Development of chronic tests for endocrine active chemicals—Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas). Aquatic Toxicology 77, 279-290. 

Juveniles and adults were the most sensitive life stages tested, and embryos and sac fry the most resistant (Smith et al. 1978, 1979 USEPA 1980 Leduc 1984)... 

Pharmacopeia First-Stage Testing (N=10) Second-Stage Testing (additional 20)... 

Cooper RL, Lamb JC, Barlow SM et al (2006) A tiered approach to life stages testing for agricultural chemical safety assessment. Crit Rev Toxicol 36(l) 69-98... 

If no growth is observed in all of the ten challenged containers, a second-stage test must be conducted to rule out the laboratory. In the second-stage test, both containers must support growth. 

Application/compendial requirements plus multipoint dissolution profiles in additional buffer stage testing (e.g., USP buffer media at pH 4.5-7.5) under standard and increased agitation conditions until >80% of drug released or an asymptote is reached Apply some statistical test (f2 test) for comparing dissolution profiles No biostudy... 

Rogers, A. R. (1963), An accelerated stage test with programmed temperature rise, J. Pharm. Pharmacol., 15,101T-105T. 

In a third stage, test bench experiments are performed over full-scale monolith catalysts feeding real engine exhausts, and the data are used for final... 

The in vitro release comparison should be carried out as a two-stage test. At the first stage, two mns of the (six cells) in vitro apparatus should be carried out, yielding six slopes (estimated in vitro release rates) for the prechange lot (R) and six slopes for the postchange lot (T). A 90% confidence interval (to be described below) for the ratio of the median in vitro release rate (in the population) for the postchange lot over the median in vitro release rate (in the population) for the... 

At this stage, test the antiserum using an appropriate assay (see Note 5). If the antibody has the requirements for the use to which it will be put, up to three further bleeds on successive days may be performed. If the antiserum is unsatisfactory, i.e., the reaction is very weak, inject the rabbit again 1 mo after the test bleed, and again test-bleed 10 d after this injection. 

Bergum, J. S. Constructing acceptance limits for multiple stage tests. Drug Dev Ind Pharm 16 2153-2166 (1990). 

Fish early life stage test (fresh and salt water)... 

Sherry, J.P, Scott, B.F and Dutka, B. (1997) Use of various acute, sublethal and early life-stage tests to evaluate the toxicity of refinery effluents, Environmental Toxicology and Chemistry 16 (11), 2249-2257. 

It takes years to develop and fine-tune a prooftest program. Time is required to identify all of the instrument loops that need to be included, and more time is needed to systematically collect or develop data sheets containing basic operational information for each device or loop. During the development stage, test methods need to be defined, and the appropriate personnel responsible for testing must be identified and trained. Finally, test frequencies must be decided. 

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