Spermatogenesis inhibition

Controls secondary male sex characteristics Maintains functional competence of male reproductive ducts and glands Increases protein anabolism maintains spermatogenesis inhibits follotropin Increases male sex behavior increases closure of epiphyseal plates... 

A subacute study in rats treated intraperitoneally with deltamethrin showed testicular degeneration and an inhibition of spermatogenesis, which seemed to be mediated by an elevation of nitric oxide levels [148], Subcutaneous dosing also produced adverse testicular effects and reduced spermatogenesis [149],... 

Mercuric chloride at a dosage of 5 mg/kg daily (i.p.) over a period of 30 days strongly inhibited spermatogenesis in rats and hamsters [237], In addition,... 

From this point of view, SOAz behaviour is strictly the same as MYKO 63 s one. Inhibition of spermatogenesis is reversible here too but the time necessary for recovering healthy spermatozoa seems shorter than for MYKO 63, i.e., about 3 weeks versus one month. 

Fertility Impairment AWhough data in humans have not been obtained regarding this effect, it is considered probable that ganciclovir, at recommended doses, causes temporary or permanent inhibition of spermatogenesis. 

Fertility Impairment It is considered probable that in humans, valganciclovir at the recommended doses may cause temporary or permanent inhibition of spermatogenesis. Animal data also indicate that suppression of fertility in females... 

Direct administration of recombinant inhibin inhibits ovulation in females (via inhibition of FSH secretion). It also inhibits spermatogenesis when administered to males. This last effect... 

So far no simple equivalent of the oral contraceptive pill has been developed for men. Relatively large doses of testosterone do inhibit gonadotrophin secretion and hence spermatogenesis, and different schedules are under clinical trial at present. 

Estrogens produce proliferative changes in the endometrium. On chronic administration, estrogen suppresses the secretion of FSH and somewhat LH resulting in inhibition of ovulation. In testes it may reduce the secretion of androgens and inhibit spermatogenesis. 

It has a potent antiandrogen and mild progestional activity. It can also inhibit gonadotropin secretion in larger dose and also suppresses spermatogenesis and Leydig cell function. It is used in precocious puberty in males, acne, carcinoma prostate and hirsutism and virilization in women. 

As mentioned several times through out this book, AAS inhibit the normal function of the HPTA (HYPOTHALAMUS PITUITARY TESTES AXIS), reduce or stop natural androgen production, and decrease spermatogenesis. This results in shrunken testes (raisin-balls). This is further discusses under "HCG" and "CLOMID" to a greater degree. Loss of sex drive can develop in long term users. 

Endocrine and Reproductive Effects. Because the male and female reproductive organs are under complex neuroendocrine and hormonal control, any toxicant that alters any of these processes can affect the reproductive system (see Chapters 17 and 20). In addition metals can act directly on the sex organs. Cadmium is known to produce testicular injury after acute exposure, and lead accumulation in the testes is associated with testicular degeneration, inhibition of spermatogenesis, and Leydig-cell atrophy. 

Cyproterone inhibits the action of androgens and gossypol prevents spermatogenesis without altering the other endocrine functions of the testis (Figure 61.9). 

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