Natural androgens

Fernandez L, Chirino R, Boada LD, Navarro D, Cabrera N, Del Rfo I, Dfaz-Chico BN (1994) Stanozolol and danazol, unlike natural androgens, interact with the low affinity glucocorticoid binding sites from male rat liver microsomes. Endocrinology 134 1401... 

Pharmacology Testosterone, produced by the Leydig cells of the testis, is the primary natural androgen. In women, small amounts are synthesized by the ovary and adrenal cortex. 

Pharmacologic doses in women stimulate growth of facial and body hair and produce deepening of the voice, enlargement of clitoris, frontal baldness and prominent musculature. Natural androgens stimulate erythrocyte production. 

It is a natural androgen secreted by testis. The secretion is regulated by LH hormone secreted by pituitary gland. 

As mentioned several times through out this book, AAS inhibit the normal function of the HPTA (HYPOTHALAMUS PITUITARY TESTES AXIS), reduce or stop natural androgen production, and decrease spermatogenesis. This results in shrunken testes (raisin-balls). This is further discusses under "HCG" and "CLOMID" to a greater degree. Loss of sex drive can develop in long term users. 

The natural androgen testosterone and a large number of other androgens and anabolic agents possess the 4,5-double bond, while the majority of metabolic products lack this unsaturation. The hypothesis was put forward that the reduction of the 4,5-double bond in the liver may represent the rate-limiting step in the inactivation of these hormones [168,221]. Upon hydrogenation of the double bond, the 5-carbon becomes asymmetric and therefore two possible isomers could result, the 5a-isomer (trans... 

Since we feel that perhaps better results can be obtained from another viewpoint, we propose to consider the mechanism of action by an approach considering the minimal structural requirements necessary to bring about hormonal activity. We must remember that the natural androgen and anabolic agent, testosterone, does not display the minimum structural requirements of active steroids —there are many steroids which are less active testosterone itself is an excellent androgen and a good anabolic agent. 

In 1960, the very fundamental postulation was made by Segaloff and Gabbard [22] that androgenic activity is a property of the hydrocarbon steroid skeleton of the natural androgen, 5a-androstane. It might be... 

Testosterone is the natural androgen secreted by the interstitial cells of the testis it is necessary for normal spermatogenesis, for the development of the male secondary sex characteristics, and for the growth, at puberty, of the sexual apparatus. It is converted by hydroxylation to the active dihy drotestosterone. 

Alexandersen, P. Haarbo, J. Christiansen, C. The relationship of natural androgens to coronary heart disease in males a review. Atherosclerosis 1996,125 (1), 1-13. 

F. Buiarelli, F. Coccioli, M. Merolle, B. Neri, A. Terracciano, Development of a LC-MS-MS method for the identification of natural androgen steroids and their conjugates in urine samples. Anal. Chim. Acta., 526 (2004) 113. 

Natural androgens (androstenedione. Myocardial infarction Mitochondrial injury ... 

The growing availability of liquid chromatography-tandem mass spectrometry (LC-MS-MS) instruments to life science researchers has sparked an exponential flurry of efforts to discover new possibilities for the detection and quantitation of anabolic steroids in a wide variety of samples. Of all the directions and applications that have been explored to date, the area of greatest potential impact on science focuses on natural androgens in human samples, as opposed to synthetic anabolic steroids or animal samples. 

Figure 2.2 Examples of natural androgen analytes in human samples. Glucuronide or sulfate conjugates of these steroids are formed with the C-3 or C-17 hydroxyl group...

Table 2.1 Summary of LC-MS analyses relevant to natural androgens in human samples... 

Perhaps due to the fact that the body has a high level of natural androgens as well as the artificial steroid hormones at that time. 

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