Fertility, impaired

Growth factor potential The possibility that epoetin alfa can act as a growth factor for any tumor type, particularly myeloid malignancies, cannot be excluded. Hypersensitivity reactions Skin rashes and urticaria are rare, mild, and transient. If an anaphylactoid reaction occurs, immediately discontinue the drug and initiate appropriate therapy. Refer to Management of Acute Hypersensitivity Reactions. Fertility Impairment In female rats treated IV with epoetin alfa, there was a trend for slightly increased fetal wastage at doses of 100 and 500 units/kg. 

Fertility Impairment A significant reduction in number of corpora lutea with consequent reduction in implantations and live fetuses was observed at 155 times the maximum recommended human dose. 

Fertility impairment Raloxifene delayed and disrupted embryo implantation resulting in prolonged gestation and reduced litter size. 

Fertility impairment Medroxyprogesterone acetate at high doses is an antifertility drug. High doses would be expected to impair fertility until the cessation of treatment. 

Fertility Impairment Fertility impairment may occur in women discontinuing OCs however, impairment diminishes with time. 

Fertility Impairment There was a dose-dependent reduction in conception rate. Pregnancy Category C. 

Fertility Impairment In a fertility study in rats, estrous cyclicity was disrupted and numbers of corpora lutea, implantations, and live embryos were reduced in females receiving the highest dose (approximately 2 times the maximum recommended human dose on a mg/m basis). 

Fertility Impairment Results of animal studies suggest the possibility of a general adverse effect on fertility in males and females. 

Fertility Impairment Oligospermia and infertility have been observed in men treated... 

Fertility Impairment Minocycline has been shown to impair fertility in male rats. Pregnancy Category D. 

Fertility Impairment Dosages of 10 mg/kg/day or greater in healthy men may, in certain unpredictable instances, produce a slight to moderate spermatogenic arrest with a decrease in sperm count. 

Fertility Impairment AWhough data in humans have not been obtained regarding this effect, it is considered probable that ganciclovir, at recommended doses, causes temporary or permanent inhibition of spermatogenesis. 

Fertility Impairment It is considered probable that in humans, valganciclovir at the recommended doses may cause temporary or permanent inhibition of spermatogenesis. Animal data also indicate that suppression of fertility in females... 

Fertility Impairment Evidence of impaired fertility was seen in female rats. 

Fertility Impairment Impairment of fertility, oligospermia, and menstrual dysfunction in humans has been reported during and for a short period after cessation of therapy. 

Fertility Impairment Menstrual irregularities were observed in monkeys administered interferon beta-la at a dose 100 times the recommended weekly human dose. Pregnancy Category C. 

Fertility Impairment Daily oral administration of imiquimod to rats throughout mating, gestation, parturition, and lactation demonstrated no effects on growth, fertility, or reproduction. 

The number of individuals affected by reproductive disorders is difficult to assess, and few population-based data are available for either men or women. Noticeably absent are data on fecundity and fertility impairments affecting men and only limited information on male-mediated developmental outcomes exists. Population-based data for impaired female fertility are available for select endpoints from the National Surveys of Family Growth (NSFG), which are conducted periodically and most recently in 1995. Data from the NSFG show that 6.2 million women (10.2%) between the ages of 15 and 44 in the United States had impaired fertility in 1995 (Stephen 1996). This number was estimated to increase to 6.3 million women in 2000 (Stephen and Chondra 1998). Other reproductive disorders in females that impact fecundity include endometriosis and polycystic ovarian syndrome (PCOS). The prevalence of endometriosis in women of reproductive age is reported to be 10% (Houston 1984 Olive and Schwartz 1993), and no population-based prevalence data exist for PCOS. 

Radiation injury causes two types of effects on biologic symptoms, stochastic and deterministic. Stochastic effects are aU or nothing effects. At increasing doses, the probability of a stochastic effect increases, but once the stochastic effect occurs, further inaeases in exposure will not worsen the severity of the effect. A conunon stochastic effect is radiation-associated malignancy. In comparison, the severity of deterministic effects is proportional to the dose. Examples of deterministic effects include suppression of hematopoiesis, cataract formation and fertility impairment (4). 

Messer HH, Armstrong WD and Singer L (1973) Fertility impairment in mice on a low fluoride intake. Science 177 893-894. 

A Combustible toxic substances 6.1 letter a), b) Very toxic Toxic Carcinogenic Fertility-impairing R26-28 R 23-25 T+/X R 39 X R48 R 45, R 49 R 60, R 61 Liquids - water-miscible with flash point >55 °C - water-immiscible with flash-point >100"G - aqueous preparations with combustic toxic substances Solids Combustion number 2, 3, 4, 5... 

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