Spectra vaccinia virus

Tenuazonic acid has a broad toxicity spectrum and is regarded as a mycotoxin [28]. It was first detected as a growth inhibitor of tumour cells (human adenocarcinoma), and was later shown to have weak antibacterial and, at high dose levels (100-500 p,g/ml), antiviral activity towards poliovirus MEF-1, enterovirus (ECHO-9), respiratory viruses (parainfluenza-3), vaccinia and Herpes simplex (HF). It has been shown to be an inhibitor of peptide bond formation in preventing substrate binding to acceptor site of peptidyltransferase in human ribosomes [29]. 

Ribavirin inhibits (he replication of a very wide variety of RNA and DNA viruses, including orthomyxoviruses, paramyxoviruses, arenaviruses, bunyavirusc,s, herpesviruses, adenoviruses, poxvirus, vaccinia, influenza virus, parainfluenza virus, and rhinovirus. In spite of the broad spectrum of activity of ribavirin, the drug has been approved for only one therapeutic indication—(he treatment of severe lower respiratory infections caused by RSV in carefully selected hospitalized infants and young children. 

Vlrazole, a -D-rlbofuranosyl derivative, has demonstrated a broad spectrum of in vitro inhibitory activity against adenovirus, HSV I and II, vaccinia, myxoma virus, parainfluenza, rhinovirus, Coxsackie virus and influenza A and B,91 it is more potent than other antl-lnfluenzal compounds in vitro and is effective against HSV keratitis and localized vaccinia. Friend leukemia virus, influenza A and parainfluenza I in vivo. The antiviral effect may be due to the inhibition of guanosine-T -phosphate synthesis in the infected cell. ... 

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