Inhibitor of growth

ING Inhibitor of growth. A family of tumour suppressors (INGl-5). ING3, 4 and 5 are found in multisubunit complexes with the Tip60, MOZ/MORF and HBOl MYST HATs. Function in a number of key cellular processes and are frequently inactivated in human cancer. 

In summary, natural products have a few known general mechanisms of action. These include toxins, inhibitors of growth, surface-energy modifiers, nervous pathway interference (anesthetics, including nitric oxide synthase inhibitors and neurotransmitter blockers), inhibitors of attachment, inhibitors of metamorphosis, and repellants.46 55117118 It is likely that many compounds have multiple mechanisms of action. 

Furthermore the syntheses of 8,10-dideazatetrahydrofolic acid and its 5-methyl- and 5-formyl derivatives (429) have been reported <93H(35)755>. The 5-/V-methyl derivative turned out to be more potent than 5,10-DDATHF as an inhibitor of growth for L1210 cells in culture but the locus of action is apparently unrelated to inhibition of GAR-Tfase. Unfortunately, 5-methyl-8,10-DDATHF was not active in vivo against an L1210 challenge in mice. 

Let consider model of dynamics of populations in the view of shortened chain (9) of two-stages - growth and division in the presence of two toxicants (inhibitors of growth) Xi and... 

Somatostatin is a cyclic tetradecapeptide hormone, characterized as the major physiological inhibitor of growth hormone released from the pituitary, but inhibits the release of many other physiologically important compounds, including insulin, glucagon, gastrin, and secretin (Wolkowitz, 1994). 

Oxysterols are reported to act as potent inhibitors of growth in mammalian cell systems because of their interference with sterol biosynthesis (13). Upon superficial examination, brassinosteroids could be regarded as just highly oxygenated sterols. Therefore, two oxysterols (24-ketolanosterol and 7-... 

Neem extracts are highly effective not only in preventing or reducing feeding by a variety of insects but also as a repellent, inhibitor of growth and development, and sterilant. A comprehensive review published by Warthen (6) in 1979 lists 20 species of the order Coleoptera (beetles), 4 species of the order Diptera (flies),... 

In toto, these results suggest that it is possible to synthesize selective inhibitors of tyrosine kinases. If these agents can be shown to be safe and effective in relevant animal models, inhibitors of growth factors, such as PDGF or erbB2, may eventually be useful as therapeutic agents. 

Inhibitor of growth and cell division in plants, inhibiting the cell (144, 275, 277,... 

The bulk of the novel chemotherapies have now become known as the small-molecule inhibitors (of growth factor cascades). Many of these agents are inhibitors of receptor tyrosine kinases (RTKs), a group of cell membrane-spanning receptors that contain intracellular tyrosine kinase domains. The intracellular tyrosine kinase domains of multiple RTK receptor subtypes... 

Bo TTA and EPA have been shovm to be inhibitors of growth of human breast cancer cells in culture. " TTA was found to have the most potent inhibitory effect on the estrogen responsive human cancer epithelial cell line MCF-7. 

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