Sorbitan trioleat

Even entrapment of entire cells within reversed micelles without loss of their functionality has been achieved. For example, mitochondria and bacteria (Actinobacter cal-coaceticus, Escherichia coli, Corynebacterium equi) have been successfully solubilized in a microemulsion consisting of isopropyl pahnitate, polyoxyethylene sorbitan trioleate [162], Enhanced hydrogen photoproduction by the bacterium Rhodopseudomonas sphaeroides or by the coupled system Halobacterium halobium and chloroplasts organelles entrapped inside the aqueous core of reversed micelles with respect to the same cells suspended in normal aqueous medium has been reported [183,184],... 

A cosolvent, typically ethanol, may be used to bring drug into solution. A small number of surfactants (sorbitan trioleate, oleic acid, and lecithin) may be dispersed in propellant systems and can aid in suspension stability and in valve lubrication. 

Poly(L-Lc) (10 g) was dissolved in 10 mL of (-caprolactone. The solution obtained was dispersed by ultrasound or by mixing in 40 mL of heptane containing sorbitan trioleate (Span 85, 3% wt/v). This dispersion was rap-... 

Polyoxyethylene sorbitan trioleate (Tween 85) sugar ester (DK-F-110) tetraoxyethylene monodecyl ether (C10E4) polyoxyethylene-p-f-octyl phenol (Triton X-100) pentaethylene glycol dodecyl ether... 

Anonymous. Final report on the safety assessment of PEG-20 sorbitan cocoate PEG-40 sorbitan diisostearate PEG-2, -5, and -20 sorbitan isostearate PEG-40 and -75 sorbitan lanolate PEG-10, -40, -44, -75 and -80 sorbitan laurate PEG-3, and -6 sorbitan oleate PEG-80 sorbitan palmitate PEG-40 sorbitan perisostearate PEG-40 sorbitan peroleate PEG-3, -6, -40, and -60 sorbitan stearate PEG-20, -30, -40, and -60 sorbitan tetraoleate PEG-60 sorbitan tetrastearate PEG-20 and -160 sorbitantriisostearate PEG-18 sorbitan trioleate PEG-40 and -50 sorbitol hexaoleate PEG-30 sorbitol tetraoleate laurate and PEG-60 sorbitol tetrastearate. Addendum to the final report on the safety assessment of... 

Maxair Pirbuterol acetate Sorbitan trioleate CFC 11, CFC 12 Suspension 3.3 13... 

Aerobid Flunisolide Sorbitan trioleate, CFC11, CFC 12, CFC Suspension 4.14 13... 

Several groups have investigated the effect of surfactants on emitted droplet size. In the early work performed by Polli et al., the surfactant sorbitan trioleate decreased the MM AD of the CFC dexamethasone suspension when added to the formulation (52). A suspension of terbutaline in a CFC system containing sorbitan trioleate surfactant was shown to have little change in emitted particle size when either 2.8 or 14mg/mL of surfactant was added (53). Interestingly, the surfactant had a significant effect on the obscuration (droplet concentration) of the laser diffraction instrument used to determine particle size. Surfactants may lead to an increase in MMAD due to decreased evaporation rates from aerosol droplets. This may occur because of their tendency to associate at the air liquid interface (54). 

The most commonly used salts in vaccine formulations are sodium chloride, sodium phosphate, succinic acid, and sodium borate. The concentrations of the salts used in any given formulation are based on isotonicity, pH, and other stabilizers being used in the formulations. A typical range is from 5 to 20 mM salt concentration. These concentrations are also selected to reduce pain on injection and to accord rapid normalization with physiological fluid. Surfactants used in MF59 emulsion include Tween 80 and sorbitan trioleate. 

Polyoxyethylene 20 sorbitan monolaurate Polyoxyethylene 20 sorbitan monopalmitate Polyoxyethylene 20 sorbitan monostearate Polyoxyethylene 20 sorbitan monooleate Sorbitan monooleate Sorbitan trioleate Sorbitan monostearate Sorbitan monopalmitate Sorbitan monolaurate Polyoxyl 35 castor oil Polyoxyl 40 hydrogenated castor oil Polyoxyethylene polyoxypropylene block copolymer... 

M. Di Maso, W. C. Purdy, S. A. McClintock, and M. L. Cotton, Determination of sorbitan trioleate in metered-dose inhalers by supercritical-fluid chromatography, J. Pharm. Biomed. Anal., 3 303 (1990). 

Since most drags are insoluble in the propellants, they are usually presented as suspensions. Micronized drag is dispersed with the aid of a surfactant such as oleic acid, sorbitan trioleate or lecithin. At concentrations up to 2% w/w the surfactant stabilizes the suspended particles by adsorption at the drag propellant interface and in addition serves as a valve lubricant. The tendency is to use minimum surfac—tant concentrations to reduce drag solubility within the propellant by solubilization (to reduce Ostwald ripening during the shelf life of the pMDI). Low surfactant concentrations will also avoid substantial reductions in the propellant evaporation rates from aerosolized drops. 

Sedimentation ratio is often used to assess suspension stability. Byron reported the sedimentation ratios for a 1% sodium fluoresein suspension formulation with different amounts of surfactant (sorbitan trioleate) after standing for 20 days at room temperature. The suspension formulation with the lowest sedimentation ratio had thebest-flocculated system. However, all formulations were easily redispersible one complete revolution of the container was sufficient to produce a homogeneous dispersion. There was no clear difference in the times taken to reach apparent sedimentation equilibrium. Physical stability of the formulation was determined according to ... 

For CFC-based suspension formulations, a surfactant was typically included. A variety of surfactants were used in these systems, e.g., lecithin, oleic acid, sorbitan trioleate. " All these surfactants were freely soluble in the CFC propellants and allowed for a degree of control over the suspension characteristics. Rates of flocculation, sedimentation, and creaming could be controlled and deposition on the internal container components was minimized. The transition to HFA-based MDIs has created significant issues in that none of the surfactants, previously used with the CFC products are soluble in HFA propellants alone. Some formulations have still used these surfactants, but the addition of a cosolvent (ethanol) has been required to solubilize the surfactant. 

Surfactants are found in both solution and suspension formulations of metered dose inhalers (MDIs). The most common surfactants found in pressurised aerosol preparations include sorbitan trioleate (Span 85),... 

Sorbitan laurate Sorbitan oleate Sorbitan palmitate Sorbitan stearate Sorbitan trioleate Sorbitan sesquioleate Sorbitani lauras Sorbitani okas Sorbitani palmitas Sorbitani sesquioleas Sorbitani stearas Sorbitani trioleas... 

Sorbitan monooleate Sorbitan monopalmitate Sorbitan monostearate Sorbitan sesquioleate Sorbitan trioleate... 

Sorbitan sesquistearate Sorbitan sesqui-octadecanoate[51938-44-4] Sorbitan triisostearate Sorbitan triisooctadecanoate [54392-27-7] Sorbitan trioleate (Z,Z,Z)-Sorbitan tri-9- [26266-58-0]... 

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