Somatic stem cells cell-based therapies

Acronyms and Definitions Mesenchymal Stromal Cells Somatic Stem Cell Therapy Good Manufacturing Practice Cell-Based Medicinal Products Human Platelet Lysate... 

Cellular therapies in transplantation and cancer are based on specific cells separated or sorted from human blood, bone marrow, or cord blood by means of their specific cell surface markers or cell differentiation antigens, e.g., CD3, CD4, CD8, CD 14, CD 19, and CD34. For example, the CD34+ stem cells, especially those derived from human embryos, have the capacity to differentiate in culture to generate different somatic cells, e.g., liver cells, heart cells, neurons, etc. This exploding field of research is now termed regenerative medicine. 

Tumorigenicity studies are also needed for certain cell therapy products based on the specific product attributes and clinical indications. Somatic cell therapy includes cells from various sources such as adult cells derived from the individual being treated (autologous), cells donated from one human to another (allogeneic), and cells from an animal source and used for human treatment (xenogeneic). Stem cell therapy includes cells derived from a variety of adult... 

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