Soluble intercellular adhesion molecule

Sublingual immunotherapy Allergy Interleukin-2 receptor Soluble intercellular adhesion molecule-1 Immunoglobulin G4 sE-selectin Interleukin Immunoglobulin E... 

For the present open observation on sublingual immunotherapy (SLIT), nonspecific inflammatory markers were chosen, which are supposed to be involved in the allergic cascade and which can be measured by common ELISA techniques soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin, soluble interleukin-2 receptor (sIL-2R), interleukin-12 (IL-12) and specific IgG4. Earlier investigations in this field were mostly performed on a smaller number of patients and the results are sometimes contradicting. 

El Sawy IH, Badr El Din OM, El Azzouni OE, Motawae HA Soluble intercellular adhesion molecule-1 in sera of children with bronchial asthma exacerbation. Int Arch Allergy Immunol 1999 119 126-132. 

Ohashi Y, Nakai Y, Tanaka A, Kakinoki Y, Ohno Y, Masamoto T, Sakamoto H, Kato A, Washio Y, Hayashi M Serum levels of specific IgE, soluble interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in seasonal allergic rhinitis. Ann Allergy Asthma Immunol 1997 79 213-220. 

Hirai S, Kageshita T, Kimura T, Tsujisaki M, Okajima K, Imai K, Ono T Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis. Br J Dermatol 1996 134 657-661. 

Laan MP, Koning H, Baert MR, Oranje AP, Buurman WA, Savelkoul HF, Neijens HJ Levels of soluble intercellular adhesion molecule-1, soluble E-selectin, tumor necrosis factor-alpha, and soluble tumor necrosis factor receptor p55 and p75 in atopic children. Allergy 1998 53 51-58. 

Ohashi Y, Nakai Y, Sakamoto H, Ohno Y, Sugiura Y, Okamoto H, Tanaka A, Kakinoki Y, Kishimoto K, Hayashi M Serum levels of soluble interleukin-2 receptor in patients with perennial allergic rhinitis before and after immunotherapy. Ann Allergy Asthma Immunol 1996 77 203-208. Ohashi Y, Nakai Y, Tanaka A, Kakinoki Y, Washio Y, Kato A, Masamoto T, Sakamoto H, Yamada K Ten-year follow-up study of allergen-specific immunoglobulin E and immunoglobulin G4, soluble interleukin-2 receptor, interleukin-4, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in serum of patients on immunotherapy for perennial allergic rhinitis. Scand J Immunol 1998 47 167-178. 

Itoh F, Suzuki A, Hinoda Y, Imai K. Double determinant immuno-polymerase chain reaction for detecting soluble intercellular adhesion molecule-1. Artif Organs 1996 20(8) 898—901. 

Respiratory syncytial virus (RSV) infection is a major cause of bronchiolitis in infants, whereas influenza A infection usually manifests as an upper respiratory tract infection. The immunological responses of infants to RSV infection and influenza A infection are different. In our studies of the cytokine responses during these infections, we found that the serum concentrations of IL-4, IL-5, RANTES, and soluble intercellular adhesion molecule-1 (sICAM-1) in infants with RSV infection were significantly higher than those with influenza A infection (S8). The concentration of TNF-a in nasopharyngeal aspirates was significantly lower in infants with RSV infection. Therefore, a predominant T helper cell type 2 (Th2) cytokine and related immunological response was observed in infants with RSV infection, whereas a predominantly proinflammatory cytokine response was observed in infants with influenza A infection. This may explain the different clinical manifestations of the two viral infections in infants (S8). 

Figure 31.4. Time coui se of cellular and molecular acdvadon folowing stioke. Diagrammadc representadon of die dme course of cellular acdvadori (PNL, polymorphonuclear leukocytes M(j), macrophages) and inflammatory molecular expression (GM, granulocyte and monocyte coloriy-sdmuladng factor ICAM, soluble intercellular adhesion molecule-1 VCAM, soluble vascular- cell adliesiori molecule-1 TNF-a, tumor necrosis factor a IL-1(5, interleukin 1(5 IL-6, interleukin 6 IL-8, interleukin 8 IL-10, interleukin 10) in human brain, cerebrospinal fluid (CSF) and blood after sUoke. Reproduced from Nilupul Perera M, Ma HK, Arakawa S, Howells DW, Markus R, Rowe CC, Donnan GA (2006). InPammation following stroke. J Clin Neurosci, 13 1-8 (with permission from Elsevier).

Rieckmann P, Nunke K, Burchhardt M, Albrecht M, Wiltfang J, Ulrich M, Felgenhauer K (1993) Soluble intercellular adhesion molecule-1 in cerebrospinal fluid An mdicator for the inflammatory impairment of the blood-cerebrospirral fluid banier. J Neuroimmurrol 47 133—140. 

Schwarz MJ, Riedel M, Ackenheil M, Muller N (2000) Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicaled and medicated schizophrenic paderits. Biol Psychia-ti-y 47 29-33. 

H. C., Maxwell, JJ., Northfield, T.C. Soluble intercellular adhesion molecule-1 in primary biUary cirrhosis relationship with disease stage, immune activity and cholestasis. Hepatology 1994 20 882-888... 

Tanne D, Haim M, Boyko V, Goldbourt U, Reshef T, Matetzky S, Adler Y, Mekori YA, Behar S. Soluble intercellular adhesion molecule-1 and risk of future ischemic stroke A nested case-control study from the bezafibrate infarction prevention (bip) study cohort. Stroke. 2002 33 2182-2186... 

Barnett CC, Moore EE, Moore FA, Biffl WL, Partrick DA Soluble intercellular adhesion molecule-1 provokes polymorphonuclear leukocyte elastase release by CD18. Surgery 1996 120 395 04. 

RB Turner, MT Wecker, G Pohl, TI Witek, E McNally, R St George, B Winther, EG Hayden. Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection. A randomized clinical trial. JAMA. 281 1797-1804, 1999. 

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