Drug-loading capacity

Drug incorporation increases with type 1 and type 11 NLC because of a reduced or lacking crystalhnity, whereas drugs dissolve in oily nanocompartments located in the sohd matrix of type HI particles. The distinct advantage of NLC compared with SLN should be the higher drug loading capacity. 

Westesen K., Bunjes H., and Koch M.H.J., Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential, J. Controlled Pel. 48, 223, 1997. 

Since liposomes have an aqueous interior, they are also termed as nanovesicles or nanocapsules. On the other hand, nanoparticulates with a solid matrix-type interior represent another type of drug carrier called nanospheres.27 Compared with liposomes, the solid interior of nanospheres generally offers a lower drug-loading capacity but at the same time provides some unique physical properties that can be advantageous in certain applications. 

Limited drug loading capacity poor stoichiometry of drug to carrier limits the mass transport mediated by the drag carrier. 

Table 2 Typical amphiphilic polymers and their drug-loading capacity...

Casalderrey M, Souto C, Concheiro A, et al. A comparison of drug loading capacity of cellactose with two ad hoc processed lactose-cellulose direct compression excipients. Chem Pharm Bull (Tokyo) 2004 52(4) 398 01. 

Pharmaceutical Properties of Nanotechnological Formulations 22.2.2.1 Drug-Loading Capacity... 

The drug-loading capacities of liposomes depend on the properties of the drug, phospholipids, and other additives used. Typically, hydrophobic drugs are solubilized... 

A variety of test methods are used to characterise drug-releasing textiles however, the main characteristics that are commonly determined are mechanical properties, morphology, degradation, chemical functionality, and of course drug-loading capacity and release kinetics. 

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