Soft drugs, definition

Cross-linked versions of water-soluble polymers swollen in aqueous media are broadly referred to as hydrogels (52) and have a growing commercial utility in such applications as oxygen-permeable soft contact lenses (qv) (53) (Table 4) and controlled-release pharmaceutical drug delivery devices (54). Cross-linked PVP and selected copolymers fit this definition and are of interest because of the following structure/performance characteristics ... 

The only article on the subject, printed in the Lancet, claimed that marijuana use caused brain damage. It was a terrible piece of work which did not even indicate all the different drugs and conditions of the population studied. Since publication of that work, there have been a number of studies, particularly in the last few years, with soft tissue X-rays that indicate definitely that marijuana use does not cause brain damage, but the original Campbell study survives. 

In its strictest definitive form, an ointment is classified as any semi-solid containing fatty material and intended for external application (U.S. Pharmocopeia, USP). In this discussion, ointments will be defined as semisolid anhydrous external preparations. In the nineteenth century, ointments were based on lard, a compounding material, the usefulness of which was severely limited by its tendency to turn rancid. Early in the twentieth century, lard was replaced by petrolatum (white or yellow soft paraffin or petroleum jelly). In present practice, nonmedicated ointments (ointment bases) are used alone, for emollient or lubricating purposes, or in combination with a drug for therapeutic purposes. 

Many makers, however, seek more or less successfully to still further increase the value of soap in this direction by the incorporation of various drugs and chemicals, and the number of medicated soaps on the market is now very large. Such soaps may consist of either hard or soft soaps to which certain medicaments have been added, and can be roughly divided into two classes, (a) those which contain a specific for various definite diseases, the intention being that the remedy should be absorbed by the pores of the skin and thus penetrate the system, and (b) those impregnated with chemicals intended to act as antiseptics or germicides, or, generally, as disinfectants. 

In the first phase of our study the minimum inhibitory concentrations (MIC) of lincomycin and BP in Ls on the basis of egg lecithin were used, which is a soft lipid and traditionally used in the creation of liposomal forms of drugs. As a result, the definition MIC of lincomycin and its liposomal preparations were found and also Ls received on the basis of egg lecithin and lincomycin are more effective than epy solution of lincomycin imder the action of Staphylococcus aureus planktonic cells (Fig. 1, Jfs2). MIC of Ls this composition decreased in 3 times in comparison with the MIC of the lincomycin solution. 

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