Drug definition

Acute gouty arthritis-50 mg 3 times/day until pain is tolerable, then rapidly reduce the dose to complete cessation of the drug. Definite relief of pain usually occurs within 2 to 4 hours. Tenderness and heat usually subside in 24 to 36 hours, and swelling gradually disappears in 3 to 5 days. Do not use sustained-release form. 

Definition and achievement of the desired physicochemical attributes of the bulk drug as needed by the dosage form development—the hulk drug definition task. 

Definitions of some Terms in the Context of Drug Design... 

Before we continue with the description of the drug discovery process, we introduce some terms commonly used in drug design and give their definitions ... 

Lead structure According to Valler and Green s definition a lead structure is a representative of a compound series with sufficient potential (as measured by potency, selectivity, pharmacokinetics, physicochemical properties, absence of toxicity and novelty) to progress to a full drug development program [12]. 

M. S. Tute, in C. A. Ramsden, vol. ed.. Comprehensive Medicinal Chemisty, Vol. A, Quantitative Drug Design, Pergamon Press, New York, 1990, pp. 1—32. Definition of Molecular Modeling and Uses of CAMM ... 

The definition of a drug differs between dictionaries and among the various professional specialisms. A search of the internet elicited various definitions and a paraphrase of the most memorable is a compound can be defined as a drug if, when injected into a rodent, it yields a scientific publication . Although this is a memorable definition, for the purposes of this review, however, a drug is defined broadly as a compound that has properties that influence the health of an animal when ingested or administered to that animal. A brief look at current literature will quickly convince the reader that this is a definition which covers man-made and natural compounds that can be extracted from plant material and microbes and iised. ... 

Electro-osmosis has been defined in the literature in many indirect ways, but the simplest definition comes from the Oxford English Dictionary, which defines it as the effect of an external electric held on a system undergoing osmosis or reverse osmosis. Electro-osmosis is not a well-understood phenomenon, and this especially apphes to polar non-ionic solutions. Recent hterature and many standard text and reference books present a rather confused picture, and some imply directly or indirectly that it cannot take place in uniform electric fields [31-35]. This assumption is perhaps based on the fact that the interaction of an external electric held on a polar molecule can produce only a net torque, but no net force. This therefore appears to be an ideal problem for molecular simulation to address, and we will describe here how molecular simulation has helped to understand this phenomenon [26]. Electro-osmosis has many important applications in both the hfe and physical sciences, including processes as diverse as water desahnation, soil purification, and drug delivery. 

In order to illustrate an example of process design for the manufacture of enantiopure drug substances on an industrial SMB system, consider manufacturing 10 ton/ year of an enantiopure drug. The racemic drug by definition is a 50 50 mixture of each enantiomer (products A and B). The goal is to process enantiopure drug substances in order to obtain 99 % purity for both the extract and the raffinate. 

---