Sodium monofluorophosphate toothpastes

Sodium monofluorophosphate is used in toothpastes to protect tooth enamel from attack by bacteria—cavities (also known as dental caries). It was developed to avoid infringing on the Crest patent for stannous fluoride. 

Anticavity toothpaste for sensitive teeth Sodium monofluorophosphate Sensodyne cool gel Cellulose gum Aqueous... 

The addition of fluoride ions to domestic water supplies (by addition of NaF) is now widespread and has resulted in a dramatic decrease in dental cavities. Fluoridated toothpastes, containing either tin(II) fluoride or sodium monofluorophosphate (MFP, Na2FP03), are also recommended to strengthen tooth enamel. 

Sodium fluoride is utilized in the manufacture of organofluoro-compounds (halogen exchange reaction), as a preservative, and as a source of fluorine for toothpaste additives (sodium monofluorophosphate). 

Tooth enamel is strengthened by the addition of fluorides (fl uoridation) to drinking water, and by the use of fluoridated toothpaste containing tin(II) fluoride, SnF2, or sodium monofluorophosphate (MFP), Na2FP03. 

Buhe H, Buttner W, Barlage B A 3-year clinical trial of toothpaste with different fluoride concentrations 0.8% and 1.2% sodium monofluorophosphate. Quintessenz 1984 35 1-9. 

AI3-16931 Albaphos Dental Na 211 Disodium fluorophosphate Disodium monofluorophosphate Disodium phosphorofluoridate EINECS 233-433-0 NSC 248 Phosphorofluoridic acid, disodium salt Sodium fluorophosphate (NazPOaF) Sodium monofluorophosphate Sodium phosphorofluoridate. A fluorine-containing component for toothpastes, the toxic effects of which are only 1/3 of those of sodium fluoride. Hoechst UK Ltd. 

EINECS 231-562-2 Fluorophosphoric acid, sodium salt MFP Phosphorofluoridio acid, sodium salt SMFP Sodium monofluorophosphate. Used in manufacture of toothpaste. Albright ... 

Dedicated benchtop NMR analyzers for a variety of applications are available. Broker s Minispec mq series (www.minispec.com) includes an analyzer to determine fluoride in toothpaste quantitatively and another to determine water droplet size distribution in oil/water emulsions. Fluoride is often added to toothpaste as sodium fluoride or sodium monofluorophosphate to prevent tooth decay. The fluorine analyzer can determine fluorine and hydrogen at the level of a few hundred ppm. Toothpaste is squeezed into a glass sample tube and the quantitative determination of fluorine takes less than 1 min. The NMR method uses no solvents or reagents and is independent of the sample color... 

About 80% of all toothpastes now sold in the United States contain fluoride compounds, usually at the level of 0.1% fluoride by mass. The most common compounds in toothpastes are sodium fluoride (NaF), sodium monofluorophosphate (Na2P03F), and stannous fluoride (SnF2). 

Precipitated calcium carbonate is inexpensive and efficient. However, it reacts easily with flnoride and hence, its nse is limited to sodium monofluorophosphate dentifrices. CaCOj, in addition to its abrasive properties, has other interesting qualities. It buffers the pH of saliva, which contributes to the formation of caries. After brushing with a toothpaste containing calcium carbonate, it dissolves into the saliva, where it works as a pH buffer. The suspended particles then adhere into certain cavities in the tooth structnre and in the plaqne. From there, they dissolve slowly into saliva, thereby prolonging the bnffering effect [16]. 

A well-formulated product will ensure a level of fluoride in the saliva above 0.02 ppm for several hours [18]. Fluoride ions are present in toothpaste formulations largely in the form of stannous fluoride (Snp2), sodium monofluorophosphate (NajPOsF), and sodium fluoride (NaF). But we can also find in the literature potassium fluoride, lithium fluoride, aluminum fluoride, zinc fluoride, acidic phosphate fluoride, ammonium fluoride, titanium tetrafluoride, and amine fluoride. 

Typical Formulation of a Toothpaste Containing Sodium Monofluorophosphate as the Source of Fluoride and Two Combined Antimicrobials... 

Toothpastes and mouthwashes are considered cosmetic oral cleansers as long as claims about them are restricted to cleaning or deodorization. Because deodorization may depend on reduction of microbiota in the mouth, several antimicrobial agents, either quaternaries, such as benzethonium chloride [121-54-0], or phenoHcs, such as triclosan [3380-35-5], are permitted. Products that include anticaries or antigingivitis agents or claim to provide such treatment are considered dmgs. Anticaries toothpaste contain sodium fluoride, stannous fluoride, and sodium monofluorophosphate. Each is approved by the FDA (47). 

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