Small pox virus

Synthetic biology uses the DNA sequence information of a virus to resynthesize the viral molecule via throughput technology of nucleotide synthesis and robotics. Using these technologies, it is possible, for example, to spread the small pox virus, and cause mass chaos which has been already eliminated from the earth. Thus, the power of synthetic biology has to be protected from terrorists just like the nuclear bombs falling in their hands. 

K. In manufacturing other products, to prohibit to use the equipment and utensils of the room dealing with small pox viruses, acute poliomyelitis viruses, spore-forming pathogens or Mycobacterium tuberculosis, with the labels attached to them for each type of product. 

Camel poxvirus—a pathogen that can attack humans, but not those who live next to camels and so are naturally immune. The Iraqis have also used this virus as a model to the small pox virus. 

A wide variety of organotin compounds developed by Carraher, Sabir, Roner, and others based on known antiviral drugs such as acyclovir and known antibacterial agents such as ciprofloxacin, norfloxacin, cephalexin (structure 11.21), and ampicillin inhibit a wide variety of viruses including ones responsible for many of the common colds, chicken pox, small pox, shingles, and herpes simplex. 

Viruses have no cell wall and made up of nucleic acid core enclosed in a protein coat which consists of identical subunits. Viruses are of two types, DNA (deoxyribonucleic acid) viruses and RNA (ribonucleic acid) viruses. DNA viruses are herpes simplex, small pox, hepatitis B, varicellazoster etc. and RNA viruses are rabies, measles, dengue, rubella, yellow fever, poliomyelitis and HIV etc. 

Agent Index A318 Class Index C27 Monkey Pox Type Virus Clinical symptoms closely resemble small pox and include extreme fatigue, fever, muscular and back pain, with evolution of maculas progressing successively to papules, vesicles, pustules, and scabs. Routes Inhalation Abraded Skin Mucous Membranes Secondary Hazards Aerosol Contact Body Fluids Fomites Incubation 7 to 15 days Mortality Rate < 15% Reservoir Monkeys, Squirrels Direct Person-to-Person Transmission is possible. 

Viruses occur in a bewildering array of sizes and shapes. Virions (complete viral particles) range from 10 nm to approximately 400 nm in diameter. Although most viruses are too small to be seen with the light microscope, a few (e.g., the pox viruses) can be visualized because they are as large as the smallest bacteria. 

Some of the organotin polypyrimidines also exhibit excellent inhibition of both the HSV-1 virus and the Vaccinia virus. [110] The HSV-1 or herpes simplex virus is responsible for at least 45 million infections in the US or one of every five adolescents and adults. The Vaccinia virus is the viral strain responsible for small pox and is considered one of the viruses that might be employed in a viral terror attack. It was also found that these pyrimidine polyamines exhibit, as solids, decent inhibition of a variety of bacteria and yeasts. [Ill]... 

Only rifampicin can prevent the development of pox viruses at concentrations completely harmless for the host cell The mechanism of action of rifampicin on these large DNA viruses is now being studied and appears different from that on bacterial cells. This is an approach to specific antiviral chemotherapy and by now the rifampicin has been shown to exert its selective activity on some large DNA viruses (pox viruses and adenoviruses type I) and on the trachoma agent However, the rifampicin activity is limited it does not prevent the replication in mammalian cells of small DNA viruses nor the RNA viruses. 

Viruses are infectious, parasitic small particles containing either DNA or RNA (but not both) encapsulated by a protein overcoat. Viruses are at the borderline of life since they neither reproduce nor carry out metabolism. Viruses are unable to reproduce or synthesize proteins because they lack some or most of the apparatus (amino acids, nucleotides, and enzymes) for replication, transcription, and translation. Viruses are responsible for a wide range of diseases—influenza, poliomyelitis, leukemia, hepatitis, smallpox, chicken pox, tumors (including cancer), and AIDS (acquired immune deficiency syndrome). 

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