Simulated optimization

Although dynamic responses of microbial systems are poorly understood, models with some basic features and some empirical features have been found to correlate with actual data fairly well. Real fermentations take days to run, but many variables can be tried in a few minutes using computer simulation. Optimization of fermentation with models and reaf-time dynamic control is in its early infancy however, bases for such work are advancing steadily. The foundations for all such studies are accurate material Balances. 

Subramanian D, Pekny JF, Reklaitis. A simulation-optimization framework for research and development pipeline management. AIChE J 2001 47(10) 2226. 

Donald E. Brown is chair of the Department of Systems Engineering of the University of Virginia. His research focuses on data fusion and simulation optimization, with ap-... 

Diwekar UM (1995) Batch Distillation - Simulation, Optimal Design and Control, Taylor Francis. 

The derivation and development of a mathematical model which is as general as possible and incorporates detailed knowledge from phenomena operative in emulsion polymerization reactors, its testing phase and its application to latex reactor design, simulation, optimization and control are the objectives of this paper and will be described in what follows. 

Planning is done by humans who use computer support tools like simulation, optimization and production planning programs. They gather information from these systems, make trial decisions and monitor the consequences. 

Method is based on the Greek term methodos meaning way towards something or way or process of examination. A method can be defined as systematic approach with respect to means and objectives that leads to technical skills in soling theoretical and practical tasks." Methods and methodological approaches are characteristic for scientific work and solution of theoretical as well as practical problems. Primary decision support method categories are shown in fig. 22 (Specker 2001, p.39) reviewed by Nienhaus (2005) reference, simulation, optimization as well as analysis and visualization. 

Value chain management is based on models using appropriate methods like reference, simulation, optimization and/or analysis and visualization. 

Gosavi A, Ozkaya E, Kahraman AF (2007) Simulation optimization for revenue management of airlines with cancellation and overbooking. OR Spectrum 29 21-38... 

Tekin E, Sabuncuoglu I (2004) Simulation optimization A comprehensive review on theory and applications. HE Transactions 36 1067-1081... 

It is becoming common practice, in today s chemical plants, to incorporate some kind of technique to rectify or reconcile the plant data. These techniques allow adjustment of the measurement values so that the corrected measurements are consistent with the corresponding balance equations. In this way, the simulation, optimization, and control tasks are based on reliable information. Figure 3 shows schematically a typical interconnection between the previous mentioned activities (Simulation Sciences Inc., 1989). 

The industrial data that is supplied in this section serves to ensure the accuracy of the students programs. Once established and verified against industrial data, these programs can be used for design, simulation, optimization, scaling-up, and parametric investigations. 

Wagner, B. J. (1995). "Recent advances in simulation-optimization groundwater management modeling." Rev. Geophys., (Supplement), 1021-1028. 

The simulation-optimization model incorporates the USGS simulation models MODFLOW (McDonald and Harbaugh 1984) and MODPATH (Pollack 1994) to determine the system state under a set of imposed stresses. More detailed discussions of the simulation-optimization model, model parameterization, and solution characteristics are presented in Mulligan and Ahlfeld (1999a) and Mulligan (1999). 

Barlow, P. M., Wagner, B. J. and Belitz, K. (1996). Pumping strategies for management ofa shallow water table The value of the simulation—optimization approach. Ground Water, 34(2), 305-317. 

Varljen, M. D. and Shafer, J. M. (1993). Coupled simulation-optimization modeling for municipal ground-water supply protection. Ground Water, 31(3), 401-409. 

SUMMARY OF SIMULATE/OPTIMIZE/PARAMETER/ RECONCILE CASES... 

Chemical Process Design, Simulation, Optimization, and Operation... 

The field of process systems engineering refers to the various techniques to design, simulate, optimize, and operate chemical processes. A majority of chemical processes operate in a continuous fashion that is, raw material is continuously fed to the manufacturing process and product is continuously produced. Large manufacturing processes often run for 18 months or more without any major shutdown. For this reason, most process systems engineering techniques have been applied to continuous processes, which are the focus of this article. Batch processes are presented elsewhere. 

---