Optimal histogram methodology, simulated

Although there are a wide variety of models for simulating protein folding, we have chosen a fairly simple force field and tethered-bead model to demonstrate the optimal histogram methodology. The basic model was first described by Honeycutt and Thirumalai to model the folded states of / -barrel structures [14,15] and has since been re-parameterized by us to model a-helical-type structures as well [16]. The specific sequence studied here... 

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