Isosulfan blue

Dyes. Vital dyes have been used for many years in a variety of clinical situations. Patent blue V (also called E131, Acid blue 3, Disulfine blue) and Isosulfan blue (also called Patent blue violet or Lymphazurine), belong to the group of triarylmethane dyes and are the most commonly used [24]. Reports of IgE-dependent anaphylaxis arise. Anaphylactic reactions involving methylene blue seems to be very rare, however, several reports of sensitization to both Patent blue and methylene blue have previously been reported. 

Visualization of Pheromone Pulses in Goldfish Urine with Isosulfan Blue... 

Injection with isosulfan blue is a relatively non-invasive and reliable method for recording urine release and yields data with high temporal resolution. The dye does not appear to affect urinary release both because urination rate does not change during the course of the experimental period used in this study (15—75 min after injection) and because fish release urine at similar rates when injected with either dye or radiation. Thus, the urination rates reported here are likely realistic. 

Patent BlueV, Isosulfan Blue, and Methylene Blue... 

Water-soluble blue dyes with and without isotope, in particular, patent blue V, isosulfan blue, and methylene blue, are being increasingly used to identify sentinel lymph nodes in melanoma patients and in cases of breast, bladder, cervical, endometrial, and other cancers. Reports of adverse reactions to blue dyes date to at least the 1960s and it is now clear that type I allergic reactions including anaphylaxis occur occasionally with all three of the above-mentioned drugs. Unfortunately, confusion surrounds the terminol-... 

Fig. 7.22 Chemical structures of dyes used for sentinel blue. The latter dye is not tilways approved for sentinel lymph node biopsies—the tiiarylmethane dyes, patent lymph node localization blue V and isosulfan blue, and the thiazine dye, methylene...

Methylene blue, or methylthioninium chloride, is a thiazine dye (Fig. 7.22, Table 7.13) unrelated in structure to patent blue V and isosulfan blue. Although not always approved for the purpose, methylene blue has been used for sentinel lymph node localization. Because it can cause necrosis on subcutaneous injection, it is generally... 

Studies in which isosulfan was used for sentinel lymph node biopsies in breast and melanoma patients showed allergic reactions in 1.42 % of patients. With regard to the severe allergic reactions (grade III), the figures were 0.44 % and 0.06 % for isosulfan blue and patent blue V, respectively. 

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