Screening, endocrine disruptors

Endocrine disruptors are nowadays considered among the most important emerging pollutants in wastewater, but they are not actually monitored on-line. A recent study [48] described the implementation of a broad-spectrum analytical scheme for the screening of more than 200 compounds (endocrine disruptors, pharmaceutical compounds,...) in urban wastewater. For other specific organic compounds, a study concerning the improvement of immunoassays with a solid-phase extraction (SPE) membrane was reported for the on-site detection in soils and water of energetic materials (i.e. explosives) [49], but unfortunately it was not really tested for wastewater. 

EDSTAC. 1998. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report. http /www.epa.gov/scipoly/oscpendo/pubs/edstac/exesuml4.pdf... 

US-EPA. 2(X)7c. US-EPA Endocrine Disruptor Screening Program - Overview website, http //www.epa. gov/scipoly/oscpendo/pubs/edspoverview/index.htm... 

The most notable coordinated effort to evaluate chemicals for potential endocrine-disrupting properties is the Endocrine Disruptor Screening Program (EDSP) directed by the EPA [37]. 

Figure 18.12 Endocrine Disruptor Screens and Modes of Action Covered in the EDSPTier I Battery (US Federal Register, 1998).

In announcing the details of the Endocrine Disruptor Screening Program (EDSP), the EPA stated that a weight-of-evidence (WOE) approach would be used to evaluate Tier I and Tier II results. Moreover, the WOE approach will include consideration of ... 

EDSTAC, Endocrine Disruptor Screening and Testing Advisory Committee HPG, hypothalamic-pituitary-gonadal PND, postnatal day p.o., per oral (by mouth) s.c., subcutaneous T4, thyroxine TSH, thyroid stimulating hormone... 

Endocrine Disruptor Screening and Testing Advisory Committee... 

Soto, A.M., Michaelson, C., Prechtl, N., Weill, B., and Sonnenschein, C., In vitro endocrine disruptor screening, in Environmental Toxicology and Assessment, Henshel, D., Ed., American Society for Testing and Materials, West Conshohocken, PA, 1999. 

USEPA (2009a) Endocrine disruptor screening program (EDSP). United States Environmental Protection Agency, Washington, http //www.epa.gov/scipoly/oscpendo/index.htm. Cited 28 January 2009. 

The term endocrine disruptors was first used by Theo Colborn and Peter Thomas in 1992. In 1996, the US Environmental Protection Agency (EPA) convened a panel called the Endocrine Disruptors Screening and Testing Advisory Committee to make recommendations to EPA concerning endocrine disruptors. The term endocrine disruptors has been used interchangeably with hormonally active agents and endocrine modulators. As the term is used now, endocrine disruptors include any substance that affects the synthesis, secretion, transport, binding, action, inactivation, or elimination of natural hormones in the body. 

US EPA (2000) Endocrine Disruptor Screening Program -Report to Congress. US Environmental Protection Agency, August. 

NICEATM. NICEATM pre-screen evaluation of the in vitro endocrine disruptor assay (Robotic MCF-7 cell proliferation assay of estrogenic activity), chttp // iccvamniehsnihgov/methods/endodocs/CCiPrescreenEvalpdf>. Accessed November 1, 2006. 

---