Hormonally active agent

US NRC (1999) Hormonally active agents in the environment. Washington, DC. US National Research Council, National Academy Press. 

Glassner, B. The Culture of Fear (New York Basic Books, 1999) National Research Council Committee on Hormonally Active Agents in the Environment, Hormonally Active Agents in the Environment (London Penguin Books, 1999). 

National Research Council, Hormonally Active Agents in theEnviron-ment (Washington, D.C. National Academy Press, 1999). 

Rudel, R.A., Brody, J.G., Spengler, J.C., Vallarino, J., Geno, P.W., Sun, G. and Yau, A. (2001) Identification of selected hormonally active agents and animal mammary cardnogens in commercial and residential air and dust samples. Journal of the Air el Waste Management Association, 51, 499-513. 

Table 55-5. Hormonally Active Agents Dosages and Toxicities. ...

Any one of a series of effects caused by hormonally-active agents that alter the homeostatic function of hormone or physiological system under the control of hormone(s). Volume 1(14), Volume 2(1). 

Selevan et al., 2000). This has been worked out in some detail for certain systems and agents (e.g. central nervous system development and radiation exposure) in most cases, however, the exact time when organ systems are susceptible to the actions of toxic chemicals is unknown. Limited data are available on susceptibility during the adolescent period, but with the current greater interest in the effects of hormonally active agents, more information is becoming available. 

The term endocrine disruptors was first used by Theo Colborn and Peter Thomas in 1992. In 1996, the US Environmental Protection Agency (EPA) convened a panel called the Endocrine Disruptors Screening and Testing Advisory Committee to make recommendations to EPA concerning endocrine disruptors. The term endocrine disruptors has been used interchangeably with hormonally active agents and endocrine modulators. As the term is used now, endocrine disruptors include any substance that affects the synthesis, secretion, transport, binding, action, inactivation, or elimination of natural hormones in the body. 

Safe SH, Connor K, Raamamorthy K, et al. 1998. Estrogenic activity of hydroxylated polychlorinated biphenyls (PCBs) and their interactions. In Eisenbrand G, ed. Hormonally active agents in food Symposium. Weinheim, ERG Wiley-VCH, 200-207. 

Endocrine-Disrupting Chemicals, Endocrine Disruptors, and Hormonally Active Agents... 

Any reproductive toxicant capable of endocrine disruption can also be considered an endocrine-disrupting chemical (EDC) or an endocrine disrupter. Another term frequently used with respect to endocrine disruption, especially regarding xenobiotics that interact with endogenous hormone receptors, is hormonally active agent (HAA). In most instances, "EDC," "endocrine disrupter," or "HAA" can be used interchangeably to discuss the actions of a given xenobiotic (Evans, 2007). 

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