Endocrine Disruptor Screening and

EDSTAC. 1998. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report. http /www.epa.gov/scipoly/oscpendo/pubs/edstac/exesuml4.pdf... 

Figure 18.12 Endocrine Disruptor Screens and Modes of Action Covered in the EDSPTier I Battery (US Federal Register, 1998).

EDSTAC, Endocrine Disruptor Screening and Testing Advisory Committee HPG, hypothalamic-pituitary-gonadal PND, postnatal day p.o., per oral (by mouth) s.c., subcutaneous T4, thyroxine TSH, thyroid stimulating hormone... 

Endocrine Disruptor Screening and Testing Advisory Committee... 

The term endocrine disruptors was first used by Theo Colborn and Peter Thomas in 1992. In 1996, the US Environmental Protection Agency (EPA) convened a panel called the Endocrine Disruptors Screening and Testing Advisory Committee to make recommendations to EPA concerning endocrine disruptors. The term endocrine disruptors has been used interchangeably with hormonally active agents and endocrine modulators. As the term is used now, endocrine disruptors include any substance that affects the synthesis, secretion, transport, binding, action, inactivation, or elimination of natural hormones in the body. 

In announcing the details of the Endocrine Disruptor Screening Program (EDSP), the EPA stated that a weight-of-evidence (WOE) approach would be used to evaluate Tier I and Tier II results. Moreover, the WOE approach will include consideration of ... 

Soto, A.M., Michaelson, C., Prechtl, N., Weill, B., and Sonnenschein, C., In vitro endocrine disruptor screening, in Environmental Toxicology and Assessment, Henshel, D., Ed., American Society for Testing and Materials, West Conshohocken, PA, 1999. 

Endocrine disruptors are nowadays considered among the most important emerging pollutants in wastewater, but they are not actually monitored on-line. A recent study [48] described the implementation of a broad-spectrum analytical scheme for the screening of more than 200 compounds (endocrine disruptors, pharmaceutical compounds,...) in urban wastewater. For other specific organic compounds, a study concerning the improvement of immunoassays with a solid-phase extraction (SPE) membrane was reported for the on-site detection in soils and water of energetic materials (i.e. explosives) [49], but unfortunately it was not really tested for wastewater. 

Vigeh M, Yokoyama K, Ramezanzadeh F et al (2006) Lead and other trace metals in preeclampsia a case-control study in Tehran. Iran Environ Res 100(2) 268-275 Wagner M, Oehlmann J (2011) Endocrine disruptors in bottled mineral water estrogenic activity in the e-screen. J Steroid Biochem Mol Biol 127(1-2) 128-135... 

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