Cell-scaffold interaction

For certain types of cells, the transfection levels are higher in 3D than in 2D 

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Enhancing tissue regeneration by controlling cell-scaffold interaction and the necessity to accommodate cellular metabolic demands through scaffold diffusivity were two fundamental scaffold-design requirements enunciated in the early 1990s (Cima et ah, 1991 Langer et ah, 1990). 

Cell-cell interactions and cell-scaffold interactions have been shown to unprove viability and stabilize function. Complete understanding of the mechanisms required to stabilize hepatocyte function will have a broad impact on this technology. 

Much of the plethora of new research in cell-scaffold interactions should be considered in the development of the ideal scaffold. The implementation of these new technologies will depend on the incorporation and preferably covalent binding of the receptor and the maintenance of its activity during the culmring process. ... 

Hydrogels are 3D networks of polymeric chains which are formed via covalent or noncovalent cross-linking reactions. They provide a favorable environment for cell growth due to high biocompatibility and could be used as an injectable format to fill tissue defects. Moreover, many hydrogels are resistant to nonspecific protein adsorption and therefore have been widely studied as potential platforms for the incorporation of proteins and peptides in ECM to control cell-scaffolds interactions. The capability to absorb large amounts of water allows for the entrapment and sustainability of the release of growth... 

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