Salicylic acid small quantities

Eugenol (80-90%), acetyleugenol (2-3%), caryophyllene, furfural, methyl amyl ketone, salicylic acid (small quantity) Clove stem oil, cedarwood, copaiba or gurjun oil, phenol, oil of turpentine. Chief test estimation of eugenol... 

Coumarin, or extract of Tonka beans, which contain coumarin, may be detected as follows A small quantity of the essence is evaporated to dryness, the residue fused with caustic potash, saturated with hydrochloric acid and treated with a drop of ferric chloride solution. If coumarin be present, a violet colour due to the formation of salicylic acid, will be produced. 

In addition to salicylic and acetic acids, very small quantities of acetylsalicylanhy-dride (0.0012 to 0.024%) and acetylsalicylsalicylic acid (0.03 to 0.1%) have been found in aspirin preparations. The former has been determined by gas chromatography,1 0 TLC170 and spectrophotometry,171 the latter by gas chromatography. 14 0,1 a controversy is still ongoing (cf. 152) whether the occasionally observed hypersensitivity against aspirin is caused by these two impurities and whether the basis of the adverse reaction is immunological. 

Evidently the non-aqueous phase may possess acidic or basic characters either in virtue of its own properties, e.g. nitrobenzene and aniline, or through the addition of small quantities of soluble acidic or basic substances, e.g. salicylic acid to salicylaldehyde or methylamine to nitrobenzene. 

Direct halogenation of salicylic acid is generally carried out in glacial acetic acid. As expected, the main product is the 5-halo-salicylic acid with small quantities of the 3-halo and 3,5-dihalosalicylic acids. 

Drugs that contain 5-aminosalicylic acid (5-ASA) have been used successfully for decades in the treatment of inflammatory bowel diseases (Figure 62-8). 5-ASA differs from salicylic acid only by the addition of an amino group at the 5 (meta) position. Aminosalicylates are believed to work topically (not systemically) in areas of diseased gastrointestinal mucosa. Up to 80% of unformulated, aqueous 5-ASA is absorbed from the small intestine and does not reach the distal small bowel or colon in appreciable quantities. To overcome the rapid absorption of 5-ASA from the proximal small intestine, a number of formulations have been designed to deliver 5-ASA to various distal segments of the small bowel or the colon. These include sulfasalazine, olsalazine, balsalazide, and various forms of mesalamine. 

Acids, Esters the former sometimes occur in small quantities free (acetic, propionic, butyric, valeric and hydrocyanic acids) and more frequently in combination with the above-mentioned alcohols as esters (formic, acetic, valeric, myristic, tiglic, cinnamic, salicylic, etc., esters). 

A colorimetric method of estimating small quantities of uranium in solution depends upon the red colour obtained when a uranyl salt is treated with sodium salicylate. Free mineral acid, iron, acetic add, alcohol, or acetone must be absent, but neutral alkali salts do not interfere. 

To 50 mg of sublimed caffeine in a tared test tube add 38 mg of scilicyclic acid and 2.5 mL of dichloromethane. Heat the mixture to boiling and add petroleum ether (a poor solvent for the product) dropwise until the mixture just turns cloudy, indicating the solution is saturated. If too much petroleum ether is added then clarify it by adding a very small quantity of dichloromethane. Insulate the tube in order to allow it to cool slowly to room temperature, and then cool it in ice. The needle-like crystcils are isolated by removing the solvent while the reaction tube is in the ice bath. Evaporate the last traces of solvent under vacuum and determine the weight of the derivative and its melting point. Caffeine salicylate is reported to melt at 137°C. 

The detection of added boric acid is somewhat difficult because a small quantity of it is normally present in certain wines. Therefore a quantitative determination should be made. The determination of SO2 must also be quantitative. A small quantity of salicylic acid is also normal in wine, and for that reason not more than 50 cc. of the sample should be used in testing for that preservative. 

Methyl Alcohol, CH3OH.—Compounds occur in certain plants from which methyl alcohol can be easily obtained in small quantities. When methyl salicylate (oil of wintergreen), which is present in checkerberries, is heated with a solution of sodium hydroxide, methyl alcohol and the sodium salt of salicylic acid are obtained. The alcohol is formed, along with other substances, when wood is subjected to destructive distillation. This method is used in the industrial preparation of methyl alcohol, which is commercially known as wood-spirit. 

Protocatechuic acid is found in a number of soft fruits and vegetables in the form of glucosides (Table 1), generally much less abundantly than those of />-hydroxybenzoic acid [1,2], except in onion peel, where it is prominent [21]. Salicylic and gentisic acids have been reported in very small quantities in the... 

The oil contains d-a-pinene, d-limonene, traces of palmitic acid, salicylic add, and a phenol, small quantities of esters of formic and valerianic acids, and a sesquiterpene of specific gravity 0 910, and refractive index 1-5030. 

Assay for sodium salicylate To 5 ml add 10 ml of dilute hydrochloric acid and extract with six 25-ml quantities of chloroform. Combine the extracts, wash with successive small quantities of water until the washings are free from chloride and then evaporate the chloroform at as low a temperature as possible, under a jet of air. Dissolve the residue in 10 ml of neutral 95 per cent ethanol and titrate with 0 1 N sodium hydroxide using phenolphthalein as indicator. 1 ml 01N = 0 01601 g. 

Micellar solutions of detergents such a sulfonates, phenolates and salicylates enhance the solubilizing properties of succinimide additives. For small concentrations of about 0.25% w/w sulfonate and 2.8% succinimide, a synergistic effect is observed, but for high sulfonate concentrations, the quantity of acid solubilized is less than that observed for succinimide alone (Bradley and Jaycock, 1972). A different mechanism exists for the solubilization of those weak acids and for strong acids. The different interaction between the amine groups in the polar head of a succinimide micelle and a weak acid (WH), and for a strong acid (SH), indicates that the weak acid is much better solubilized as ... 

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