Ritodrine

Chemical Name ervthro-p-hydroxy-a-[1-[(p-hydroxyphenethyl)amino] ethyl] benzyl alcohol 

Common Name N-(p-hydroxYphenYlethvl)-4-hydroxYnorephedrine Structural Formula , ---- 

Trade Name Manufacturer Country Year Introduced 

2-Bromo-4 -benzyloxypropiophenone 2-(4-Methoxyphenyl)ethylamine Hydrogen bromide 

A solution of 44 grams of 2-bromo-4 -benzyloxypropiophenone and 44 grams of 2-(4-meth-oxyphenyOethylamine in 270 ml of ethanol was refluxed for 3 hours. Then the ethanol was distilled off in vacuo and the concentrate mixed with ether. The resulting crystailizate was sucked off after which the filtrate was mixed with an excess of 2N hydrochloric acid. As a result of this the hydrochloride of 4 -benzYloxY-2-[2-(4-methoxYphenYl)ethylamino]-propiophenone slowly crystallized. This substance was also sucked off, washed with water and alcohol, and dried In vacuo. After recrystallization from dilute alcohol the yield was 25.5 grams of a product with a melting point of 217° to 218°C. 

12 grams of the product thus obtained were dissolved in a mixture of 300 ml of ethanol and 90 ml of water. After 42 ml of 1% palladium chloride solution and 3.9 grams of Norit had been added to this solution it was hydrogenated at room temperature and at a pressure of 1.1 atmospheres until approximately 760 ml of hydrogen had been taken up. Then the catalyst was removed by filtration and the solvent of the filtered solution was evaporated entirely in vacuo. 

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Yamacillin Taiempiciiiin Yamafur Carmofur Yatrociclina Methacycline Yatrocin Nitrofurazone Yesdol Diphenidol YIestrol Ethinylestradiol Yobir Alprenolol HCI Yocio Clofibrate Yomesan Niclosamide Yonomol Inositol niacinate Yophadoi Diphenidol Yosimilon Trimetazidine Youfural Tegafur Ytrocin Erythromycin Yubekinon - Ubidecarenone Yurinex Bumetanide Yutopar Ritodrine Yxin Tetrahydrozoline HCI... 

Adrenergic receptor agonists are also used to treat premature labour by causing uterine relaxation. Fenoterol and ritodrine are frequently used. The effectiveness of long-term tocolysis is controversial, since both desensitization of the receptors and the symptomatic nature of this treatment may limit their effects to 1-2 days according to one large study. 

Ritodrine has an effect on beta (p)2-adrenergic receptors, principally those that innervate the uterus. Stimulation of these p2-adrenergic receptors inhibits uterine smooth muscle contractions. The pradrenergic receptors are located in the heart and are not stimulated by ritodrine when administered as prescribed. Ritodrine is used to... 

Alterations in fetal and maternal heart rates and maternal blood pressure frequently occur when ritodrine is administered IV. Additional frequent adverse reactions associated with IV administration include nausea, vomiting, headache, palpitations, nervousness, restlessness, and emotional upset. A rare, but serious, adverse reaction is pulmonary edema... 

There is a decreased effectiveness of ritodrine when the drug is administered with a -adrenergic blocking agent such as propranolol and an increased risk of pulmonary edema when administered with the corticosteroids. Co-administration of ritodrine with the sym-pathomimetics potentiates the effect of ritodrine. Cardiovascular effects (eg, arrhythmias or hypotension) of ritodrine may increase when the drug is administered with diazoxide, general anesthetics, magnesium sulfate, or meperidine... 

Before starting an IV infusion containing ritodrine or terbutaline, the nurse obtains the patient s vital signs. The nurse auscultates lung sounds to provide a baseline assessment. The nurse places the patient on a monitoring device to determine uterine contractions and the FHR before and during administration. 

Develop a nursing care plan for Ms. Morris, a 28-year-old, woman who is admitted to the obstetric unit with premature labor during her third trimester. This is her second child, and die has had two miscarriages. She is prescribed ritodrine for preterm labor. Analyze what nursing diagnoses would have the highest priority. Discuss how you would explore and plan to meet her emotional needs. 

During administration of ritodrine, in what position would die nurse most probably place the patient ... 

C16H14O2 4495-66-3) see Buphenine Ifenprodil Isoxsuprine Oxilofrine Ritodrine 3(7J)-benzyloxytetradecanal (C21H34O2 112763-97-0) see Orlistat... 

The only drug that has been lieensed for the treatment of preterm labour in the US is ritodrine, a /1-2 adrenoceptor agonist. -2 Adrenoceptors are... 

The answer is e. (Hardman, p 215 J Ritodrine hydrochloride is a selective [ -adrenergic agonist that relaxes uterine smooth muscle. It also has the other effects attributable to J3-adrenergic receptor stimulants, such as b rone hod il at ion, cardiac stimulation, enhanced renin secretion, and hyperglycemia. 

Ritodrine (378) hydrochloride was also stable in infusion solutions containing glucose, but in the presence of riboflavin it photo-oxidized to 77-hydroxybenz-aldehyde [220]. See also the photosensitized reaction of pyridoxine. 

Ritodrine relaxes the uterine muscle and is therefore indicated to prevent premature labour. Ergometrine, oxytocin and carboprost are all indicated to induce or augment labour by inducing uterine contractions and hence can be used to cause the uterus to contract after delivery. Dinoprostone is mostly used for the induction of labour. 

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