Ritodrine hydrochloride

The answer is e. (Hardman, p 215 J Ritodrine hydrochloride is a selective [ -adrenergic agonist that relaxes uterine smooth muscle. It also has the other effects attributable to J3-adrenergic receptor stimulants, such as b rone hod il at ion, cardiac stimulation, enhanced renin secretion, and hyperglycemia. 

If labour begins prematurely, before 33 weeks gestation, myometrial relax-ants (tocolytic agents) can delay it for 48 hours. Beta-2-agonists, such as ritodrine hydrochloride, are given for up to 48 hours to elicit relaxation. Longer treatment is not recommended, because of risk of adverse effects on the mother. Nifedipine and the oxytocin receptor antagonist atosiban are also used to reduce premature uterine contractile activity. 

Dose. 50 to 350 pg/min of ritodrine hydrochloride by intravenous infusion up to 120 mg daily, by mouth. 

Ritodrine Hydrochloride Normethadone Hydrochloride Phendimetrazine Tartrate... 

Ritodrine hydrochloride, 961 Rivanol, 591 Rivea corymhosa, 714 Rivotril, 480 Robmnol, 752 Robamox, 348, 351... 

Toxic epidermal necrolysis has been attributed to intravenous ritodrine in a 26-year-old woman at 35 weeks of gestation a lymphocyte stimulation test with ritodrine hydrochloride was positive [57 ]. 

Yasuda R, Makino Y, Matsuda Y, Kawamichi Y, Matsui H. Agranulocytosis associated with intravenous ritodrine hydrochloride therapy two case reports by different mechanisms. J Obstet Gynaecol Res 2012 38(3) 574-7. 

Shiba M, Kido K, Umezawa K, Higaki H, Matsumoto S, Taguchi A, Hayashi T, Higaki Y, Sasamori Y, Shinozuka N, Fuse Y, Kikuchi A, Ayabe T. Erythematous and bullous rash strongly indicating toxic epidermal necrolysis associated with the use of intravenous ritodrine hydrochloride. J Obstet Gynaecol Res 2010 36(3) 676-80. 

Nakajima Y, Masaoka N, Tsuduki Y, Honda N, Sakai M. Rhabdomyolysis caused by tocolytic therapy with oral ritodrine hydrochloride in a pregnant woman with placenta previa. J Obstet Gynaecol Res 2011 37(6) 629-32. 

Musculoskeletal Rhabdomyolysis with severe generalized weakness and muscle pain occurred when a pregnant woman without a history was given ritodrine hydrochloride ... 

Hematologic Ritodrine hydrochloride has been widely used for tocolysis, although serious side-effects have been reported. The following two cases represent ritodrine-induced agranulocytosis with possibly different mechanisms. 

Two patients were hospitalized because of preterm labour and were given i.v. ritodrine. The nadir of neu-trocytes was 199/mm and 13/mm in the two cases, respectively. The total dose of ritodrine hydrochloride was calculated to be 7800 mg for 26 days and 2500 mg for 22 days, respectively. The total doses were heavier and administration duration was longer in Case 1, which... 

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