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Risk assessment performance

More attention lias been recently focused on exposure assessment. Tliis is because many of the risk assessments performed in tlie past used too many and overly conservative assumptions. This in turn, caused an overestimation of the actual exposure. [Pg.353]

Risk assessment performed at first prenatal visit with random glucose screen. [Pg.648]

From the results of this study, the conclusion can be drawn that the dislodgeable results tend to be variable from site to site and that the mean of the Cenvir term will be dependent on the method of dislodging used on the turf. What is important is the magnitude of the final calculated transfer coefficient, which is also very dependent on the task that was done when generating the Dpot results. The differences produced by the different techniques for collecting the exposure data will affect the risk assessments performed using the data. [Pg.149]

In 1995, the US-EPA updated and issued the current Agency-wide Risk Characterization Policy (US-EPA 1995). The Policy called for all risk assessments performed at US-EPA to include a risk characterization to ensure that the risk assessment process is transparent. It also emphasized that risk assessments should be clear, reasonable, and consistent with other risk assessments of similar scope prepared by programs across the Agency. [Pg.350]

Since one of the main aims of green chemistry is to reduce the use and/or production of toxic chemicals, it is important for practitioners to be able to make informed decisions about the inherent toxicity of a compound. Where sufficient ecotoxicological data have been generated and risk assessments performed, this can allow for the selection of less toxic options, such as in the case of some surfactants and solvents [94, 95]. When toxicological data are limited, for example, in the development of new pharmaceuticals (see Section 15.4.3) or other consumer products, there are several ways in which information available from other chemicals may be helpful to estimate effect measures for a compound where data are lacking. Of these, the most likely to be used are the structure-activity relationships (SARs, or QSARs when they are quantitative). These relationships are also used to predict chemical properties and behavior (see Chapter 16). There often are similarities in toxicity between chemicals that have related structures and/or functional subunits. Such relationships can be seen in the progressive change in toxicity and are described in QSARs. When several chemicals with similar structures have been tested, the measured effects can be mathematically related to chemical structure [96-98] and QSAR models used to predict the toxicity of substances with similar structure. Any new chemicals that have similar structures can then be assumed to elicit similar responses. [Pg.422]

While all GxP data should be checked for correctness, it may be possible to justify a sample check for other data categories if a business case can be made to justify the omission of checks on all records. Some regulators require a double check for GxP data entry. Such checks should immediately follow the data entry and precede any further processing of the data. Where this is not possible, checking must be conducted as soon as possible and a risk assessment performed to address the potential consequences of erroneous data input. [Pg.262]

We proceed carefully even in large enterprises to win them over in their duty to have a risk assessment performed in their workplaces leaving aside the inclusion of measuring occupational exposure (an expensive exercise) as a separate issue to be ined in due course. ... [Pg.242]

In establishments of B class having less than 20 employees and where the employer himself takes over the tasks of the Safety Engineer, s/he is obliged to have a written risk assessment performed by a person having a UD or TEI and specialty relevant to his economic activity in cordance with article 5 of P.D.294/S8. [Pg.244]

Mapping of existing practice and performing risk assessment is hence limited to 60 archetypes instead of the vast numbers of components being in the network. E.g. the risk assessment performed for the component archetype poles in Table 2 then applies to the many thousand poles which are found in the network. [Pg.386]

Development of the legislative reqnirements for the use of limits of acute toxicity can help to achieve a better compatibihty and enable the comparison of risk evaluation processes connected with toxic substances. This could strongly improve the decision process of risk assessment performed by managing authorities responsible for EEP, as well as those preparing and evaluating the safety documents. [Pg.887]

Figure 2.71 shows an example SCF thread for the brake function in an automobile system. It was determined from FHA of this hypothetical system that the brake function was safety-critical, because if the braking function failed when needed it could lead to a loss of life mishap. All of the systems (or subsystems) in the brake function are identified in this thread and they in turn become safety-critical. Further HA can now be performed on these critical components and a risk assessment performed. Derived design safety requirements can be generated for each element as necessary to mitigate unacceptable risk. This thread can be used to understand the HCFs and their interrelationships within the thread. [Pg.351]

When the PSV needs to be removed and worked on, the equipment the PSV is protecting will be shut in, both PSV isolation valves will be closed, the equipment will be depressurized, the PSV removed, and blinds installed on both open ends of the isolation valve flanges. Where 100% online capacity can be maintained while working on a parallel PSV, and the PSV can be safely isolated (risk assessment performed), shutting in the equipment, and depressurizing is not required. [Pg.296]


See other pages where Risk assessment performance is mentioned: [Pg.405]    [Pg.524]    [Pg.99]    [Pg.32]    [Pg.244]    [Pg.80]    [Pg.405]    [Pg.405]    [Pg.304]    [Pg.121]    [Pg.643]    [Pg.289]    [Pg.41]    [Pg.738]    [Pg.223]    [Pg.50]   
See also in sourсe #XX -- [ Pg.132 ]




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