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Retinoic acid peels

For more mild sun damage, a series of retinoic acid (1— 10% peels can also be performed. A series of 3-4 peels are done at 2 week intervals. If a patient s sun damage is more pronounced, a combination of superficial peels can employed. In this case, the Jessner or Salicylic acid (20-30% peel is applied first followed by the retinoic acid peel. The retinoic acid peel imparts a yellowish hue to the skin during its application period, which is then rinsed off with water at home by the patient in 4—6 hours. Postpeel care is similar to other superficial peels. [Pg.120]

Topical retinoic acid is applied initially in a concentration sufficient to induce slight erythema with mild peeling. The concentration or frequency of application may be decreased if too much irritation occurs. Topical retinoic acid should be applied to dry skin only, and care should be taken to avoid contact with the corners of the nose, eyes, mouth, and mucous membranes. During the first 4-6 weeks of therapy, comedones not previously evident may appear and give the impression that the acne has been aggravated by the retinoic acid. However, with continued therapy, the lesions will clear, and in 8-12 weeks optimal clinical improvement should occur. A timed-release formulation of tretinoin containing microspheres (Retin-A Micro) delivers the medication over time and may be less irritating for sensitive patients. [Pg.1295]

If we leave aside these variables, we can fit the dilferent types of peels into their appropriate slots. This is just for the beauty of the exercise however, as the variables stiU need to be taken into account. It is clearly possible to perform a superficial or medium peel using phenol. But, given the inherent toxicity of phenol, what would be the point What is more, 70% unbuffered glycolic acid that is left for 10-15 minutes on a thin, sensitive skin that has been prepared with retinoic acid can result in a cosmetic disaster. It is possible to carry out good-quality, deep peels with TCA, but the risks can be greater than if phenol is used correctly. [Pg.3]

As a general rule, it is worthwhile preparing the skin carefully with tyrosinase inhibitors if there is any risk of post-peel pigmentary changes or to optimize results when treating melasma. Retinoic acid and sometimes glycolic acid are used to make transepidermal penetration more even or to deepen the action of the acid solution. [Pg.5]

All common types of acne can be treated with TCA. Severe acne, such as acne necrotica , acne conglobata or acne fulminans , should first be treated medically and the inflammation eliminated before the cosmetic use of peels. Oral isotretinoin (13-cis-retinoic acid) is the gold-standard treatment for severe acne (Box 13.1), but new retinoids come to light regularly. [Pg.102]

Retinol induces the expression of retinoic acid-binding protein (RABP) and regulates cell migration in the skin epithelium, which is vital for skin regeneration after a peel. Encapsulating retinol provides better bioavailability of the vitamin and protects the skin against oxidation. Ker-atinocytes have the enzyme tools required to convert retinol into retinoic acid (the corresponding carboxylic acid), which is the molecule ultimately responsible for the effect of vitamin A. [Pg.111]

Patients who have used isotretinoin (13-ds-retinoic acid, Roaccutane ) or other more recent retinoids during the previous year or are going to use it within the next 12 months should be ruled out from medium or deep peels. Some authors even suggest leaving a gap of 2-3 years between isotretinoin and a peel, as this product ... [Pg.345]

Applying topical tretinoin (aU-frans-retinoic acid) before a peel can often reduce the incidence of miHa. However, the undesirable effects of retinoic acid in combination with a deep or medium peel must be taken into account. Retinoic acid increases the depth of penetration of caustic agents, could increase the risk of hyperpigmentation and, if it is applied too soon after a medium or deep peel, slows down the rate of re-epithelialization. [Pg.358]

Garg VK, Sarkar R, Agarwal R (2008) Comparative evaluation of beneficiary effects of riming agents (2% hydroquinone versus 0.025% retinoic add) in the treatment of melasma with glycohc acid peels. Dermatol Surg 34 1032—1039... [Pg.191]

A soft peeling with 25% salicylic acid or 40% pyruvic acid or 5% retinoic acid can reduce the pigmentation. Absolute sun avoidance. [Pg.198]

Skin priming consists of topical application of compounds, such as retinoic acid 0.05%, glycolic acid 10%, pyruvic acid 7%, and hydroquinone 2-4%, used alone or in combination, for at least 2 weeks before the peel procedure. These agents used in the pre-peel period cause a superficial exfoliation due to keratino-cyte discohesion, and allow a more uniform, rapid, and deeper penetration [11]. [Pg.202]

In commenting on Khunger et al. s [308] study, Kligman [309] notes that the pH of the tretinoin (all-trans retinoic acid) solution is approximately 6.0 and that, unlike TCA and glycolic acid, does not cause epidermal neaosis [309]. Rather, tretinoin causes a delayed peeling action due to an inflammatory response [309]. A 0.25 % tretinoin solution in 50 % ethanol and 50 % polyethylene glycol 400 has also been used [310]. [Pg.172]

When considering chemical peelings we are only interested in the natural retinoids - retinol, all-trans retinal and retinoic acid - the last two of which are useful in strong concentrations as peeling agents used under medical supervision. [Pg.13]

The retinoid for progressive peel step IV can be either retinyl propionate 10%, retinol 1%, retinyl aldehyde 0.5% or retinoic acid 0.1 %. They are interchangeable. [Pg.60]

Cosmeceutical pharmaceutical agents are commonly combined with chemical peels to enhance exfohative and regenerative effects. Retinoic acid preparations are prescribed as daily home care to accelerate epidermal proliferation, so there is an increase in epidermal thickness despite the stratum corneum being shed. The application of retinoic acid enhances the effectiveness of light and even medium-depth chemical peeling to texture, tone, and smooth the skin. Used in combination with alpha-hydroxy acids (AHAs) retinoic acid prepares the skin for the peel procedure. [Pg.137]

The development of milia, or inclusion cysts, after a chemical peeling typically occurs about 2 to 3 weeks after reepithelialization. The occurrence of these is probably exacerbated by the use of emollient creams that can occlude the pilosebaceous ducts. Retinoic acids used before and after the peel can decrease the occurrence of milia. Since the retinoic acids can interfere with wound healing and may cause further irritation, it is best to resume them only after erythema has subsided. The treatment for inclusion cysts is extraction by needle or lancet, or electrodessication. Because milia will usually regress spontaneously, it is also acceptable to defer treatment unless the patient asks for extraction. [Pg.179]


See other pages where Retinoic acid peels is mentioned: [Pg.82]    [Pg.12]    [Pg.82]    [Pg.12]    [Pg.110]    [Pg.202]    [Pg.23]    [Pg.24]    [Pg.25]    [Pg.70]    [Pg.91]    [Pg.101]    [Pg.130]    [Pg.135]    [Pg.137]    [Pg.275]   


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