Skin priming

TCA, the following classification can be used as a general guideline for TCA peels. It is imperative to keep in mind, however, that the results are dependent on multiple factors including type/thickness of skin, priming of skin, and technique of application of the TCA ... 

Skin priming is necessary to improve peel results and reduce risks of complications. Priming allows an easier and more uniform penetration of the peeling agent. 

Skin priming consists of topical application of compounds, such as retinoic acid 0.05%, glycolic acid 10%, pyruvic acid 7%, and hydroquinone 2-4%, used alone or in combination, for at least 2 weeks before the peel procedure. These agents used in the pre-peel period cause a superficial exfoliation due to keratino-cyte discohesion, and allow a more uniform, rapid, and deeper penetration [11]. 

Immune Defense. Figure 1 Innate immune responses after challenge of skin or mucosa Acute inflammation and priming of adaptive immunity. 

Skin Models Implicate a Role for Mast Cells in Priming of Adaptive Immune Responses and Allergic Sensitization... 

The role of CD8-I- T cells in atopic skin inflammation is still not well defined. It has been shown that CLA-I-CD8-I- T cells isolated from the circulation are as potent as CLA+CD4-I- T cells in the induction of IgE and enhancement of eosinophil survival. This suggests that these cells have more than bystander functions in atopic dermatitis. Recent data from a mouse model indicate that allergen-primed CD8+ T cells are required for the development of atopic dermati-tis-like lesions in vivo [19]. 

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