Response thermoregulatory

Second, we can compare this hypothesis with the well-known fact that body temperature declines at sleep onset but then remains constant in REM despite a complete loss of central thermoregulatory reflex response in that state Because aminergic demodulation characterizes REM, it precludes a rise in body temperature (unless ambient temperature were suddenly to rise). The strong central cholinergic activation of REM may contribute to the loss of thermoregulatory reflex responsiveness in that state. 

Fibrous proteins represent a substantial subset of the human proteome. They include the filamentous structures found in animal hair that act as a protective and thermoregulatory outer material. They are responsible for specifying much of an animal s skeleton, and connective tissues such as tendon, skin, bone, cornea and cartilage all play an important role in this regard. Fibrous proteins are frequently crucial in locomotion and are epitomised by the muscle proteins myosin and tropomyosin and by elastic structures like titin. Yet again the fibrous proteins include filamentous assemblies, such as actin filaments and microtubules, where these provide supporting structures and tracks for the action of a variety of molecular motors. 

Jequier, E. (1975). Direct calorimetry. A new clinical approach for measuring thermoregulatory responses in man. Bibl. Radiol. 6,185-190. 

Hypothermia associated with hypothalamic and thermoregulatory dysfunction has been reported in a patient with Prader-Willi syndrome taking risperidone and olanzapine (222). Hypothermia in response to these drugs is said to result from 5-HT2 receptor blockade, and it is recommended that patients with hypothalamic dysfunction should be carefully monitored if risperidone or olanzapine are used. 

Basically, the pyrogen test involves measuring the rectal temperature of rabbits, both prior to and after the intravenous injection of a test solution in the ear veins. If the animals exhibit febrile responses that exceed established limits, the test solution is judged to be pyrogenic. Rabbits became the animal of choice because they are relatively inexpensive, are easy to handle, and have a labile thermoregulatory mechanism. Rabbits frequently produce false-positive pyrogen... 

The authors claimed that this was the first report of this problem. Referring to the observation that baclofen injection into the cerebral ventricles can produce fever in rats (15), they assumed that rostral spread of baclofen could have initiated a thermoregulatory response via the chemo-trigger zone in the third ventricle. They suggested that a percutaneous subarachnoid catheter could facilitate the decision to either proceed with or abort surgical catheter or pump implantation when baclofen is associated with fever. 

Erythromycin may reduce the normal thermoregulatory response to hyperthermia. Erythromycin has been associated with hyperthermia in foals. Treated foals that are turned out on hot, sunny, humid days develop fever, tachypnea and distress, which may result in fatal heat stroke. 

In cases of long bone injury in man and the rat, Cuthbertson and his colleagues have shown that the protein metabolic response to injury is considerably reduced by exposure to 30°C (C4a, C5, C40) short-term thermoregulatory adaptation did not seem to be involved. 

Much of the previous work has been conducted on animals, often studied under anesthesia, even though anesthetic agents can grossly distort thermoregulatory response. Moreover, there are marked differences in some of the basic modes of thermal compensation between animals and man—in an attempt to relieve an excessive heat load, for instance, some mammals including man sweat, whereas others such as the dog pant. Animal studies can be valuable in developing general concepts,... 

There is evidence that thermal sensors are distributed throughout the body. In animals sensors have been reported in the heart of the rabbit (6), the pulmonary vessels of sheep (7), and the spinal cord of the dog (8). However, it is agreed that some of the most important thermal receptors in the human are found in the anterior hypothalamus and the skin. The sensors at either of these locations can initiate thermoregulatory responses, and it is important that the action generated by each type of sensor be evaluated. However, most studies reported previously reflect the total response induced by both of these sources of sensory input acting together. 

Hypothennia is the most frequently observed thermoregulatory response of mice, rats, and other relatively small mammals when they ine administered acute doses of anti-ChE insecticides while being maintained at an ambient temperature below their ihermoneulral zone (Gordon et ai, 1988 Gordon, 2004). Many of the studies that have... 

A hypothermic response in a rodent exposed to an anti-ChE as well as many other toxicants has often been concluded to represent a dysfunction or failure of the thermoregulatory... 

Overall, it appears that fever is the mo.sl frequent thermoregulatory response in humans acutely exposed to anti-ChEs, On the other hand, an acute hypothermic effect of OP and CM insecticides has occasionally been reported in humans poisoned with anti-ChEs. In one instance, a 16-year-old male suffering from OP poisoning... 

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