Response multimodal

Cancer treatment is a multimodality treatment, i.e., surgery is combined with radiotherapy and antineoplastic chemotherapy. The latter treatment mode is used mainly for cancers which have disseminated. Different forms of cancer differ in their sensitivity to chemotherapy with antineoplastic agents. The most responsive include lymphomas, leukemias, choriocarcinoma and testicular carcinoma, while solid tumors such as colorectal, pancreatic and squamous cell bronchial carcinomas generally show a poor response. The clinical use of antineoplastic agents is characterized by the following principles. 

Health care providers use a multimodality approach including surgery and chemotherapy in the initial treatment of ovarian cancer with a curative intent. Although most patients will achieve a complete response initially, more than 50% of cancers will recur within the first 2 years,2,35 Complete response to treatment is defined as no evidence of disease can be detected by physical examination or diagnostic tests, and patient has a normalized CA-125 value. 

Huang, K.S., Mark, D. and Gandenberger, F.U. (2006) High-throughput measurements of biochemical responses using the plate vision multimode 96 minilens array reader. Methods in Enzymology, 414, 589-600. 

The MARS-S is constituted of a multimode cavity very close to domestic oven with safety precautions (15 mL vessels up to 0.5 L round-bottomed flasks, magnetic stirring, temperature control). The magnitude of microwave power available is 300 W. The optical temperature sensor is immersed in the reaction vessel for quick response up to 250 °C. A ceiling mounted is available in order to make connection with a conventional reflux system located outside the cavity or to ensure addition of reactants. These ports are provided with a ground choke to prevent microwave leakage. It is also possible to use a turntable for small vessels with volumes close to 0.1 mL to 15 mL vessels (120 positions for 15 mL vessels). Pressure vessels are available (33 bar monitored, 20 controlled). 

MTA Cooperative Group (1999b) Moderators and mediators of treatment response for children with attention-deficit/hyperactiv-ity disorder the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder. Arch Gen Psychiatry 56 1088-1096. 

Psychopharmacologic treatment of aggression should occur within an individualized multimodal treatment plan and be based on an understanding of the psychiatric disorder, target symptoms, and available pharmacological treatments. Pharmacological intervention requires close monitoring of response over time. 

Taniguchi T, Takaoka A. 2002. The interferon-alpha/beta system in antiviral responses A multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol. 14 111-116. 

Although the systems investigated here exhibited predominantly macropore control (at least those with pellet diameters exceeding 1/8" or 0.32 cm), there is no reason to believe that surface diffusion effects would not be exhibited in systems in which micropore (intracrystalline) resistances are important as well. In fact, this apparent surface diffusion effect may be responsible for the differences in zeolitic diffusion coefficients obtained by different methods of analysis (13). However, due to the complex interaction of various factors in the anlaysis of mass transport in zeolitic media, including instabilities due to heat effects, the presence of multimodal pore size distribution in pelleted media, and the uncertainties involved in the measurement of diffusion coefficients in multi-component systems, further research is necessary to effect a resolution of these discrepancies. 

In the example given, the constitutive equation used is a multimode Phan Tien Tanner (PTT). It requires the evaluation of both linear and nonlinear material-response parameters. The linear parameters are a sufficient number of the discrete relaxation spectrum 2, and r]i pairs, which are evaluated from small-strain dynamic experiments. The values of the two nonlinear material-response parameters are evaluated as follows. Three semiarbitrary initial values of the two nonlinear parameters are chosen and the principal normal stress difference field is calculated for each of them using the equation of motion and the multimode PTT. They are compared at each field point (i, j) to the experimentally obtained normal stress difference and used in the following cost function F... 

To investigate these findings further the authors determined heating rates of the employed multimode instruments and the Discover unit, once again using toluene as solvent. After 10 min irradiation at a constant maximum power output for each microwave reactor, different final temperatures were measured (Fig. 17). Furthermore, it could be shown that the observed differences in temperature are not only related to the different heating efficiencies of the instruments but also to the specific vessel material [27]. Usually the vessel material itself is not completely microwave-transparent and therefore it is at least partially responsible for heating of the irradiated solvent via conventional thermal conduction [42]. 

Yang T-S, Vohringer P, Arnett DC, Scherer NF. The solvent spectral density and vibrational multimode approach to optical dephasing two-pulse photon echo response. J Chem Phys 1995 103 8346-8359. 

The different organomagnesium species present may propagate at different rates and with different stereochemistries. Their persistence during the lifetime of the polymer chains is thought to be responsible for the multimodal molecular weight distributions and heterogeneity of tacticity observed in many systems [34]. Accordingly, one could view the polymerization process as an amplifier. ... 

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