High-throughput measurement

Avdeef, A. High-throughput measurements of solubility profiles. In Pharmacokinetic Optimization in Drug Research Biological, Physicochemical and Computational Strategies, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. (eds.), VHCA, Zurich and Wiley-VCH, Weinheim, 2001, pp 305-325. 

Some of the compUcations Usted above could be flagged and, sometimes, remedied in a manual shake-flask experiment, but that is unlikely to be the case in automated shake-vial procedures, especially if performed in a 96-well plate setting. Nevertheless, the demands of modern pharmaceutical discovery operations emphasize high-throughput measurements, low compound consumphon... 

Avdeef, A., High-throughput measurements of permeability profiles, in van de Waterbeemd, H. Lennemas, H. Artursson, P. (eds.), Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability Wiley-VCH Weinheim, 2003 (in press)... 

Aucamp, J.P., Cosme, A.M., Lye, G.J. andDalby, P.A. (2005) High-throughput measurement of protein stability in microtiter plates. Biotechnology and Bioengineering, 89, 599-607. 

Huang, K.S., Mark, D. and Gandenberger, F.U. (2006) High-throughput measurements of biochemical responses using the plate vision multimode 96 minilens array reader. Methods in Enzymology, 414, 589-600. 

Box, K., Bevan, C., Comer, J., Hill, A., Allen, R., Reynolds, D., High throughput measurement of pKa values in a mixed-buffer linear pH gradient system. Anal. Chem. In press. 

High-throughput measurements, including informatics and mathematics for interpretation of large-volume data streams ... 

Dehring, K.A. et al. 2004. Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility. J. Pharm. Biomed. Anal. 36 447. 

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