Respiratory syncytial virus , asthma

Currently, 17 mAbs have been approved in the United States (US) for therapeutic use in organ transplant, percutaneous coronary intervention, prophylaxis of respiratory syncytial virus, RA, Crohn s disease, asthma, chronic lymphocytic leukemia (CLL), acute myeloid leukemia, non-Hodgkin s lymphoma, breast cancer, and colorectal cancer. All approved mAbs are of the IgG class 13 human IgG1 one igG4, and two murine IgG2a. Thirteen are intact mAbs, three are conjugated, and one is a Fab fragment (Tables 12.2 to 12.4). 

Mejias A, Chavez-Bueno S, Rios AM, Fonseca-Aten M, Gomez AM, Jafri HS, Ramilo O. Asma y virus respira-torio sincitial. Nuevas oportunidades de intervencion tera-peutica. [Asthma and respiratory syncytial virus. New opportunities for therapeutic intervention.] An Pediatr (Bare) 2004 61(3) 252-60. 

Dosimetry Drug dose and distribution/response to therapy 1 -5 pm Asthma, cystic fibrosis, COPD, bronchopulmonary dysplasia, respiratory syncytial virus, diabetes, adult respiratory distress syndrome... 

Sigurs N, Bjarnason R, Sigurbeigsson F, Kjellman B Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000 161 1501-1507. 

Some early respiratory infections, e.g. pertussis and bronchiolitis caused by respiratory syncytial virus, as well as some forms of gastro-enteritis may enhance the development of allergic diseases and asthma. 

Effect of anti-viral agents to treat bronchiolitis induced by respiratory syncytial virus and to prevent asthma in young children at high risk. 

Viral infections are primarily responsible for exacerbations of asthma. Viral upper respiratory tract infections are a major precipitant of acute asthma in children, being involved in up to 20% to 40% of acute episodes. Infants are particularly susceptible to airways obstruction and wheezing with viral infections because of their small airways. The most common cause of exacerbations in both children and adults is the common rhinovirus." Other viruses isolated include respiratory syncytial virus (RSV), parainfluenza virus, coronavirus, and influenza viruses. The inflammatory response to viral infection is thought to be associated directly with the increasing BHR. Certain viruses (RSV and parainfluenza virus) are capable of inducing spe-... 

The exacerbation of asthmatic responses is most frequently caused by a pulmonary viral infection, such as influenza, rhino, or adenovirus infections (81-89). Recent data has indicated that rhinoviral infections are the most common cause of severe asthma exacerbations. In addition to exacerbating asthmatic responses, severe respiratory syncytial virus (RSV) infections early in childhood appears... 

Respiratory viral infections, including adenovirus, influenza, metapneumovirus, parainfluenza, rhinovirus, and respiratory syncytial virus (RSV), are the primary cause of asthma exacerbations in both children and adults... 

Pullan, C. R., and Hey, E. N. (1982). Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br. Med. J. (Clin Res Ed) 284,... 

Reactive airway disease (viral induced ) and asthma Respiratory syncytial virus... 

Sigurs N, et al. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiohtis a prospective cohort study with matched controls. Pediatrics 1995 95(4) 500-550. 

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