Anti-viral agents

This is an anti-viral agent that has weak levodopa-like effects but its mode of action is not really known. Since the most likely effect is considered to be the release of DA it is not surprising that its value is limited when most DA neurons have been destroyed. 

One of the subunits of the natural product (-)-macrolactin A, a strong anti-viral agent, has been synthesized as shown in the following scheme, involving the hydrotelluration of a enyne (a), and the opening of an epoxide with a vinylic higher-order cyanocuprate (b). ... 

Obviously the best treatment for cirrhosis is removal of the injurious event. In the case of viral hepatitis, viral load can at least be temporarily reduced with anti-viral agents such as lamivudine, ribavirin and/or IFNa [76]. Unfortunately, complete removal of the injurious event is frequently not possible. Moreover, by the time cirrhosis is diagnosed the fibrotic process has usually progressed beyond the point of no return and removal of the injurious event will have little effect. Successful pharmacological treatment to reverse the fibrotic... 

Viruses are obligate intracellular organisms as their replication is based on DNA and RNA dependent processes and protein synthesis of the host. Antiviral therapy can therefore not be as selective as antibacterial treatments and anti-viral agents tend to inhibit host cell function and can cause major toxicity. An other problem with antiviral therapy is the fact that active viral replication mostly takes place before symptoms become manifest. Our armamentarium against most viral infections is limited. 

The importance of the carbafuranoses stems from the interest in having access to carbocyclic analogues of nucleosides [88], which have attracted particular attention as anti-tumor and anti-viral agents, (-)-carbovir being one of the more popular synthetic target molecules [89]. (Fig. 1)... 

Ribozymes have been applied as anti-viral agents, for the treatment of cancer and genetic disorders, and as tools for pathway elucidation and target validation. Initial uses of ribozymes focused on anti-viral, primarily for the treatment of HIV (Rossi, 1999). Viruses that go through a genomic RNA intermediate in their replication cycle, such as HIV, hepatitis B virus and hepatitis C vims are attractive targets because a single... 

Job Title and Purpose. This must be precise and self explanatory, it is going to be used in the job advertisement, to attract only suitably qualified applicants, e.g. Synthetic Chemist to design and synthesise novel, organic materials for test as anti viral agents, ft is also important to note where the job will be done, e.g. in a research group, in a plant team or as part of the technical service function etc. Similarly, it should be clear to whom the person will report, e.g. to the Team Leader. 

Assign as far as possible the H spectrum " of this derivative of the anti-viral agent Virantmycin and determine the relative stereochemistry and conformation of ring B from the given NOEs. 

Daidone G, Maggio B, Schillaci D (1990) Salicylanilide and its heterocyclic analogs. A comparative study of their antimicrobial activity. Pharmazie 45 441 142 Almerico AM, Diana P, Barraja P, Dattolo G, Mingoia F, Loi AG, Scintu F, Milia C, Puddu I, La Colla P (1998) Glycosidopyrroles - Part 1. Acyclic derivatives l-(2-hydroxyethoxy) methylpyrroles as potential anti-viral agents. Farmaco 53 33 0... 

Another therapeutic application of polyhydroxylated alkaloids is as anti-viral agents. Inhibitors of processing a-glucosidases, such as castanospermine and DNJ, have been shown to decrease the infectivity of human immunodeficiency virus (HIV) in vitro at concentrations which are not cytotoxic to lymphocytes, whereas specific inhibitors of processing a-mannosidases (swainsonine and 1-deoxymannojirimycin) have no effect on Castanospermine and DNJ also reduce the infectivity of other retroviruses... 

Choudhury, A., Jin, F., Wang, D., et al. (2003) A concise synthesis of anti-viral agent F-ddA, starting from (S)-dihydro-5-(hydroxymethyl)-2(3f/)-furanone. Tetrahedron Lett., 44, 247-250. 

Effect of anti-viral agents to treat bronchiolitis induced by respiratory syncytial virus and to prevent asthma in young children at high risk. 

These have a pool of anti-viral agents acting in cooperation with certain plasticisers to maintain and increase the antiviral agent s efficacy. They may be used to make surgical gloves, condoms, surgical clothes, surgical operative fields,... 

RK Harris, RR Yeung, RB Lamont, RW Lancaster, SM Lynn, SE Staniforth. Polymorphism in a novel anti-viral agent Lamivudine. J Chem Soc Perkin Trans 2 2653, 1997. 

Uracils can be prepared via reaction of primary amines with 3-ethoxyacryloyl isocyanate this method is particularly snitable for complex amines and has fonnd much use in recent years in the synthesis of, for example, carbocyclic nncleoside analogues as potential anti-viral agents. The immediate product of amine/isocyanate interaction can be cyclised under either acidic or basic conditions the method can also be applied to thionracil synthesis by the use of the corresponding isothiocyanate. 

Carbocyclic bromovinyldeoxyuridine (CarbaBVDU) is an anti-viral agent. ... 

---