Resorcylic zearalenone

Disbold et al. [34] developed a laser fluorimetric method for the determination of zearalenone (6-(10-hydroxy-6-oxo-fra s-l-undcccnyl-/i-resorcylic acid n-lactone))-infected corn. By combining laser fluorimetry with high-pressure liquid chromatography, these workers were able to detect and quantitate the naturally fluorescent mycotoxin zearalenone in contaminated corn samples. 

Zearalenone (119) is a 14-membered resorcylic keto lactone isolated from the fungus Gibberella zeae. - Anabolic and uterotrophic activity have been exhibited by this compound. 

Note. Zearalenone is one of a group of compounds known under the more general name of RALs or resorcylic acid lactones. 

Kalivretenos K, Stille JK, Hegedus LS (1991) Synthesis of p-Resorcylic Macrolides via Organopalladium Chemistry. Application to the Total Synthesis of (S)-Zearalenone. J Org... 

Zearalenone (ZEA), a 14-membered resorcylic acid lactone, was first isolated in 1962 from the Gibberella zeae, an anamorph Fusarium graminearum [111]. Structure 145 was proposed some years later (Figure 7.44) [112]. ZEA is also produced by several other Fusarium species, including Fusarium culmorum, Fusarium... 

In 2004, trans- and cw-resorcylide were totally synthesized, and palladium-catalyzed carbonylative Stille coupling was applied for the preparation of the intermediate (Scheme 10.27) [112]. Trans- and cii-resorcylides are both natural macrocyclic plant growth inhibitors, isolated independently from different Peni-cillium species. Together with zearalenone, lasiodiplodin, and the important antitumor agent radicicol, they constimte an important class of bioactive resorcylic macrolides. 

Zearalenone and DON are secondary metabolites of several species in the fungal genus Fusarium. Zearalenone, a resorcylic acid lactone with estrogenic activity, causes reproductive problems in swine and other livestock with consume contaminated feedstuffs (Mirocha et al., 1968 Mirocha et al., 1971). Deoxynivalenol, a trichothecene... 

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