Resolution, tandem mass spectrometry

Loo fA, Quinn JP, Ryu SI, Henry KD, Senko MW, et al. 1992. High resolution tandem mass spectrometry of large biomolecules. Proc Natl Acad Sci USA 89 286. 

Meng, F.Y., Forbes, A.J., Miller, L.M. and Kelleher, N.L. (2005) Detection and localization of protein modifications by high resolution tandem mass spectrometry. Mass Spectrom. Rev., 24, 126-34. 

Wu, Q. Cheng, X. Hofstadler, S.A. Smith, R.D. Specific metal-oligonucleotide binding studied by high resolution tandem mass spectrometry. J. Mass Spectrom., 31, 669-675 (1996). 

M.W. Senko, S.C. Beu, and EW. McLafferty, High-resolution tandem mass-spectrometry of carbonic-anhydrase, Analytical Chemistry, 66, 415 17 (1994). 

However, by reducing the electric field the normal ions can be discriminated against and only the ionic products from the metastable fragmentations will be transmitted, giving pure metastable spectra. For both geometries it is possible to scan both sectors simultaneously in a linked scan , which provides low-resolution tandem mass spectrometry. 

Mo, J. Hakansson, K. Characterization of nucleic acid higher order structure by high resolution tandem mass spectrometry. Anal. Bioanal. Chem. 2006, 386, 675-681. 

Tourino S, Fuguet E, Jauregui O, Saura-Calixto F, Cascante M and Torres JL. 2008. High-resolution liquid chromatography/electrospray ionization tandem mass spectrometry to identify polyphenols from grape antioxidant dietary fiber. Rapid Commun Mass Spectrom 22 3489-3500. 

TOF analyzers are especially compatible with MALDI ion sources and hence are frequently coupled in aMALDI-TOF configuration. Nevertheless, many commercial mass spectrometers combine ESI with TOF with great success. For proteomics applications, the quadrupole TOF (QqTOF) hybrid instruments with their superior mass accuracy, mass range, and mass resolution are of much greater utility than simple TOF instruments.21,22 Moreover, TOF instruments feature high sensitivity because they can generate full scan data without the necessity for scanning that causes ion loss and decreased sensitivity. Linear mode TOF instruments cannot perform tandem mass spectrometry. This problem is addressed by hybrid instruments that incorporate analyzers with mass selective capability (e.g., QqTOF) in front of a TOF instrument. 

Moritz, T. Olsen, J.E. Comparison Between High-Resolution Selected Ion Monitoring, Selected Reaction Monitoring, and Four-Sector Tandem Mass Spectrometry in Quantitative Analysis of Gib-berellins in Milligram Amounts of Plant Tissue. Anal. Chem. 1995, 67, 1711-1716. 

Figeys, D., Lock, C., Taylor, L., and Aebersold, R. (1998). Microfabricated device coupled with an electrospray ionization quadrupole time-of-flight mass spectrometer protein identifications based on enhanced-resolution mass spectrometry and tandem mass spectrometry data. Rapid Commun. Mass Spectrom. 12, 1435 — 1444. 

Jemal, M. Ouyang, Z. Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry investigations of parameters that affect ruggedness. Rapid Commun Mass Spectrom 2003, 17, 24-38. 

McClellan, J. F. Murphy, J. R, III Mulholland, J. J. Yost, R. A. Fffects of Fragile Ions on Mass Resolution and on Isolation for Tandem Mass Spectrometry in the Quadrupole Ion Trap Mass Spectrometer. Anal. Chem. 2002, 74, 402-412. 

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