High-resolution tandem mass spectrometry

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Meng, F.Y., Forbes, A.J., Miller, L.M. and Kelleher, N.L. (2005) Detection and localization of protein modifications by high resolution tandem mass spectrometry. Mass Spectrom. Rev., 24, 126-34. 

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Mo, J. Hakansson, K. Characterization of nucleic acid higher order structure by high resolution tandem mass spectrometry. Anal. Bioanal. Chem. 2006, 386, 675-681. 

Tourino S, Fuguet E, Jauregui O, Saura-Calixto F, Cascante M and Torres JL. 2008. High-resolution liquid chromatography/electrospray ionization tandem mass spectrometry to identify polyphenols from grape antioxidant dietary fiber. Rapid Commun Mass Spectrom 22 3489-3500. 

TOF analyzers are especially compatible with MALDI ion sources and hence are frequently coupled in aMALDI-TOF configuration. Nevertheless, many commercial mass spectrometers combine ESI with TOF with great success. For proteomics applications, the quadrupole TOF (QqTOF) hybrid instruments with their superior mass accuracy, mass range, and mass resolution are of much greater utility than simple TOF instruments.21,22 Moreover, TOF instruments feature high sensitivity because they can generate full scan data without the necessity for scanning that causes ion loss and decreased sensitivity. Linear mode TOF instruments cannot perform tandem mass spectrometry. This problem is addressed by hybrid instruments that incorporate analyzers with mass selective capability (e.g., QqTOF) in front of a TOF instrument. 

F.W. McLafferty, High-resolution tandem FT mass spectrometry above lOkDa, Ace. Chem. Res., 27 (1994) 379-386. 

Moritz, T. Olsen, J.E. Comparison Between High-Resolution Selected Ion Monitoring, Selected Reaction Monitoring, and Four-Sector Tandem Mass Spectrometry in Quantitative Analysis of Gib-berellins in Milligram Amounts of Plant Tissue. Anal. Chem. 1995, 67, 1711-1716. 

Yang, L., Amad, M., Winnik, W. M., Schoen, A. E., Schweingruber, H., Mylchreest, I., and Rudewicz, P. J. (2002). Investigation of an enhanced resolution triple quadmpole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays. Rapid Commun. Mass Spectrom. 16 2060-2066. 

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