Resolution, tandem mass

Loo fA, Quinn JP, Ryu SI, Henry KD, Senko MW, et al. 1992. High resolution tandem mass spectrometry of large biomolecules. Proc Natl Acad Sci USA 89 286. 

The most common types of MS/MS instruments available to researchers in food chemistry include triple quadrupole mass spectrometers and ion traps. Less common but commercially produced tandem mass spectrometers include magnetic sector instruments, Fourier transform ion cyclotron resonance (FTICR) mass spectrometers, and quadrupole time-of-flight (QTOF) hybrid instruments (Table A.3A.1). Beginning in 2001, TOF-TOF tandem mass spectrometers became available from instrument manufacturers. These instruments have the potential to deliver high-resolution tandem mass spectra with high speed and should be compatible with the chip-based chromatography systems now under development. 

Meng, F.Y., Forbes, A.J., Miller, L.M. and Kelleher, N.L. (2005) Detection and localization of protein modifications by high resolution tandem mass spectrometry. Mass Spectrom. Rev., 24, 126-34. 

Wu, Q. Cheng, X. Hofstadler, S.A. Smith, R.D. Specific metal-oligonucleotide binding studied by high resolution tandem mass spectrometry. J. Mass Spectrom., 31, 669-675 (1996). 

M.W. Senko, S.C. Beu, and EW. McLafferty, High-resolution tandem mass-spectrometry of carbonic-anhydrase, Analytical Chemistry, 66, 415 17 (1994). 

However, by reducing the electric field the normal ions can be discriminated against and only the ionic products from the metastable fragmentations will be transmitted, giving pure metastable spectra. For both geometries it is possible to scan both sectors simultaneously in a linked scan , which provides low-resolution tandem mass spectrometry. 

The term Analytical Power refers to the amount of analytical information that can be derived from an analytical instrument. Greater analytical power of an instrument results in more reliable detection, identification and quantitation of samples of interest. For example, a very high degree of analytical power can be derived from a Gas Chromatograph - High Resolution Tandem Mass Spectrometer instrument while... 

Mo, J. Hakansson, K. Characterization of nucleic acid higher order structure by high resolution tandem mass spectrometry. Anal. Bioanal. Chem. 2006, 386, 675-681. 

The electrospray and continuous flow-FAB experiments were carried out on a Finnigan-MAT TSQ700 triple quadrupole low resolution tandem mass spectrometer and a JEOL four sector HXllO/HXllO magnetic high resolution tandem mass spectrometer, respectively. The electrospray ionization source was manufactured by Analytica of Branford, CT. The MALDI experiments were done on a Vestec-2000 time-of-flight mass spectrometer equipped with a nitrogen laser. Chromatographic purifications of standards were performed on Applied Biosystems HOB microbore HPLC systems. 

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