Receptors oncogenes

Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (2004) The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Oncogene 23 559-568... 

Sharma SV, Gajowniczek P, Way IP et al. A common signaling cascade may underlie addiction to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell2006 10 425 35. 

Klapper, L. N., Vaisman, N., Hurwitz, E., Pinkas-Kramarski, R., Yarden, Y., and Sela, M. (1997). A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors. Oncogene 14, 2099-2109. 

Nandurkar HH, Hilton DJ, Nathan P, et al. The human IL-11 receptor requires gpl30 for signaHing demonstration by molecular cloning of the receptor. Oncogene 1996 12 585-93. 

See also Second Messenger Systems, Hormone Receptors, Oncogenes and Cell Signalling, Diabetes, Action of Insulin... 

Eisemann, A. Ahn, J.A. Graziani, G. Tronick, S.R. Ron, D. Alternative splicing generates at least five different isoforms of the human basic-FGF receptor. Oncogene, 6, 1195-1202 (1991)... 

Longati, P. et al., Tyrosines 1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor), Oncogene, 9,49,1994. 

Gil J, Esteban M (2000) The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-ot receptors. Oncogene 19 3665-3674... 

The relationship between the two receptors for NGF is complex and not yet completely understood. It has been suggested that the functional form of the NGF receptor is a heterodimer of p75 and pl40 proteins. BDNF and NT-3 bind to p75, but the functional receptors for these neurotrophins are the proto-oncogene products of and trkQ. 

Marmor MD, Yarden Y (2004) Role of protein ubiquity la-tion in regulating endocytosis of receptor tyrosine kinases. Oncogene 23 2057-2070... 

Johnston LD, O Malley PM, Bachman JG, et al Monitoring the Future National Results on Adolescent Drug Use Overview of Key Findings, 2003 (NIH Publ No 04—3506). Bethesda, MD National Institute on Drug Abuse, 2004 Jorda MA, Rayman N, Valk P, et al Identification, characterization, and function of a novel oncogene the peripheral cannabinoid receptor Cb2. Ann N Y Acad Sci 996 10-16, 2003... 

Sun L., Fuselier J.A., Murphy W.A., Coy D.H. Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma 1M.R.32 cells expressing somatostatin receptors. Peptides 2002 23 1557-1565. 

Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998 391(6662) 86-89. 

Wang J, Zhang X, Thomas SM, et al. Chemokine receptor 7 activates phosphoinositide-3-kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGER. Oncogene 2005 24 5897-5904. 

Many non-receptor tyrosine kinases have been identified as products of retrovirally encoded oncogenes. Non-receptor tyrosine kinases can be divided into two groups transmembrane and cytosolic families. The c-src tyrosine kinase is the prototype of the cytosolic tyrosine kinases. Regions within these non-receptor tyrosine kinases share homology with the Src kinase, known as Src homology 2 and 3 (SH2 and SH3) domains, and mediate protein-protein interactions between the receptor tyrosine kinases and the intracellular targets (reviewed in Cantley et al., 1991 Pawson and Gish, 1992 Mayer and Baltimore, 1993). 

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