Receptor binding properties

Grinevich, V.P., Letchworth, S.R., Lindenberger, K.A. et al. Heterologous expression of human alpha 6 beta 4 beta 3 alpha 5 nicotinic acetylcholine receptors binding properties consistent with their natural expression require quaternary subunit assembly including the alpha 5 subunit. J. Pharmacol. Exp. Then 312 619, 2005. 

Kennedy DO, Wake G, Savealev S, Tildesley NTJ, Perry EK, Wake G, Wesnes KA and Scholey AB (2003b). Modulation of mood and cognitive performance following administration of single doses of Melissa officinalis (lemon balm) with human CNS nicotinic and muscarinic receptor binding properties. Neuropsychopharmacology, 28, 1871-1881. 

Several reports are available on the biological activities of thioamide derivatives. The thioamide derivatives have shown significant activities, such as antituberculosis drug, anti-influenza virus activity, antitumor activity, anthelmintic activity, opioid receptor binding property, etc.94 101... 

Lastly, it has been shown that in rare cases trisulfide bridges (Cys-SSS-Cys) can be found as hydrophobic variants of recombinant proteins. The experimental mass of such a trisulfide-bridged peptide would be increased by 32 amu. Andersson et al.125 have described this phenomenon for recombinant human growth hormone during expression in E. coli. However, the receptor binding properties were not affected by this trisulfide modification. 

F. Liang, H.A. Navarro, P. Abraham, P. Kotian, Y.S. Ding, J.S. Fowler, N.D. Volkow, M.J. Kuhar, F.l. Carroll, Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2 -fluoro-5 -pyridinyl)-7-azabicyclo-[2.2.1 (heptane A new positron emission tomography ligand for nicotinic receptors, J. Med. Chem. 40 (1997) 2293-2295. 

Amoxapine has been found to be effective in several double-blind studies (Table 7-4 and Table 7-6). It is a dibenzoxazepine derivative that has both NE and serotonin uptake inhibiting properties. Amoxapine is converted into 8-hydroxyamoxapine, which has considerable dopamine receptor binding properties (i.e., radioreceptor bioassays on patients given amoxapine have found activity levels similar to those of patients on typical antipsychotics), a chemical structure similar to loxapine, and effects similar to antipsychotics (1Q3). As a result of this metabolite, amoxapine theoretically may have unique beneficial effects in psychotically depressed patients. However, this possibility has never been adequately tested. Nevertheless, this metabolite is likely responsible for some of the antidopamine effects reported in patients taking amoxapine, including acute and chronic extrapyramidal side effects and elevated prolactin levels ( 104). Like TCAs, amoxapine can be lethal in... 

Bodesheim U, Holz J. Isolation and receptor binding properties of alkaloidsand ligands from Valeriana officinalis. Pharmazie 1997 52 386-391. 

Leysen, J.E., Gommeren, W., Niemegeers, C.J. [3H]Sufentanil, a superior ligand for mu-opiate receptors binding properties and regional distribution in rat brain and spinal cord, Eur. J. Pharmacol. 1983, 87, 209-225. 

A series of transformations in l-benzhydrylazetidine-2-carboxylate 110 has led to the synthesis of l-benzhydryl-2-aminoalkylazetidines 111, known to have ORL-1 receptor binding properties (Scheme 23) <2002BML3157>. 

Persico, M. G., Vincenti, V., and DiPalma, T. 1999. Structure, expression and receptor-binding properties of placenta growth factor (P1GF). Curr. Top. Microbiol. Immunol. 237 31 —40. 

Objective The objective of this analysis was to develop a population PK/PD model based on the data after intravenous administration that allows to explore in silico which absorption characteristics would be required for other administration routes and/or which receptor binding properties are crucial for backup compounds. 

The cloning of the delta receptor set in motion a competitive race to identify other members of the opioid receptor family. Homologous orphan clones were quickly assessed for opioid receptor binding properties, which resulted in the identification of the kappa receptor and reassignment of an orphan clone as the delta opioid receptor [31]. PCR, genomic, and cDNA screens revealed the mu opioid receptor and an extremely abundant orphan member, named opioid receptor-like (ORL-1) receptor (reviewed by Massotte and Kieffer [30]). 

Grasso P, Heindel JJ, Powell CJ, Reichert LE Jr (1993) Effects of mono(2-ethylhexyl)phthalate, a testicular toxicant, on follicle-stimulating hormone binding to membranes of cultured rat Sertoli cells. Biol Reprod 48 454-459 Ketelslegers JM, Catt KJ (1974) Receptor binding properties of 125-hFSH prepared by enzymatic iodination. J Clin Endocrin Metab 39 1159-1162... 

Vincent J-P (1995) Neurotensin receptors binding properties, transduction pathways, and structure. Cell Mol Neurobiol 75 501-511. 

Otto, A. M., A one minute pulse of estradiol to MCF-7 breast cancer cells changes estrogen receptor binding properties and commits cells to induce estrogenic responses. J. Steroid Biochem. Mol. Biol. 54, 39-46 (1995). 

The pharmacological auxiolytic agent (38) has been used to study the receptor binding properties of compounds of this type and the mechanism of their action. 

One method that has been used to acquire carbohydrates is isolation and purification from natural sources such as human or animal tissue, milk, urine, plants, and bacteria (see cross reference Isolation of glycans). Access to homogeneous carbohydrate stmctures can be challenging due to the difficulties in separation of complex mixtures, identification of carbohy-drate(s) contained within each fraction, and preparation of sufficient quantities from the limited amounts present in a particular sample. Alternatively, mixtures of unknown composition can be used to survey a broad repertoire of the glycome. On identification of a mixture containing one or more members with interesting receptor-binding properties, the mixture can then be deconvoluted by further fractionation and separation by routine analytical techniques (13). 

Gantchev, T.G., Ali, H. and Vanlier, J.E. (1994). Quantitative Structure-Activity Relationships Comparative Molecular Field Analysis (QSAR/CoMFA) for Receptor Binding Properties of Halogenated Estradiol Derivatives. J.Med.Chem., 37,4164-4176. 

Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL. 1993. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem. Pharmacol. 45 1129-36... 

Gantchev TG, Ali H, van Lier JE. Quantitative structure-activity relationships/ comparative molecular field analysis (QSAR/CoMFA) for receptor-binding properties of halogenated estradiol derivatives. J Med Chem 1994 37 4164-76. 

Stahl SM, Shayegan DK. The psychopharmacology of ziprasidone Receptor-binding properties and real-world psychiatric practice. J Clin Psychiatry 2003 64(Suppl 19) 6-12. 

Gomparison of electrotopological-state indices versus atomic charge and superdelocalisability indices in a QSAR study of the receptor binding properties of halogenated estradiol derivatives. Mol. Div., 8, 343-355. 

Receptor binding properties for xanomeline, CDD-0102 and two bivalent derivatives at M, and M2 receptors expressed in A9 L cells Binding data (K values) were from competition assays utilizing [ H](/ )-QNB as the radioligand. Data represent the mean ( S.E.M.) from two to five assays for each compound, n.d., not determined. 

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