Receptors properties

Glennon, R.A, Young, R. Bennington, F. and Morin, R.D. Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen l-(2,5-dimethoxyphenyl)-2-aminopropane. J Med Chem 25 1163- 1168, 1982. 

One test that was carried out when trying to compare levamisole receptor properties in SENS and LEVR isolates was to count the numbers of patches of recorded membranes that contained active channels. Figure 21.7 shows the proportion of patches from SENS and LEVR isolates that contained active patches at different concentrations of levamisole. It was... 

Glennon, R. A., Leming-Doot, D., and Young, R. (1981) DOM and related 2,5-dimethoxy-4-alkylphenylisopropylamines Behavioral and serotonin receptor properties. Pharmacol. Biochem. Behav., 14 287-292. 

Calculation Methods for Critical Loads of Heavy Metals The selection of a computation method or model is the third step in the flowchart for calculating critical loads of heavy metals (Figure 4). There are different models that can be used to calculate critical loads for terrestrial and aquatic ecosystems, based on receptor properties and on certain critical limits. Relevant aspects in relation to the selection of a calculation method are... 

The functionality that is often necessary for a chiral crown ether to serve a particular purpose can usually be introduced by the synthetic chemist without too much difficulty. The practice here, however, can be very much more demanding on account of the promiscuous receptor properties of the compounds that have to be separated and isolated pure from reaction mixtures containing many components. 

Schematic representations, like those shown in the Scheme 1, are very useful to indicate the chemical composition of the various species and to discuss the interaction between the various building blocks. Furthermore, as one can understand from the representations shown in Figures 9 and 10, the species with high nuclearity exhibit a ttu-ee-dimensional branching structure of the type of those shown by otherwise completely different dendrimers based on organic components. Therefore, endo- and exo-receptor properties can be expected, which are currently under investigation. Furthermore, aggregation of decanuclear complexes has also been demonstrated by dynamic light-scattering and conductivity experiments. Systematic studies on aggregation properties have, however, not been performed yet.

The receptor properties of quetiapine are similar to those for olanzapine and risperidone. This medication is rapidly absorbed, reaching peak plasma concentrations in 1.5 hours. It is metabolized by the liver. 

Organic lumophores can also be used in conjunction with receptor,-spacer-receptot2 systems. Aminoalkyl cyclodextrins are particularly suitable in this regard since amines and cyclodextrins show almost mutually exclusive receptor properties. 

Molecular recognition with rhodium complexes of functionalized porphyrins - The coordination abilities of rhodium(III) porphyrins outlined in Scheme 3 (paths b and g) were used to design porphyrins with special receptor properties, i.e. cis-or trans-5,15-bis(2-hydroxy-l-naphthyl)octaethylporphyrin [H2(npOEP)], trans-5,15-bis(8-quinolyl) porphyrin, or tetrakis(2-hydroxyphenyl) porphyrin. After Rh insertion, these porphyrins provide lateral OH or N donor groups at a fixed distance from the coordination site at the Rh atom. Unlike RhCl(TPP), RhCl(npOEP) activates acetone in a manner that an a-metallation of acetone takes place, yielding Rh(CH2COMeXnpOEP) [283]. 

Chabot C., Gagne J., Giguere C., Bernard J., Baudry M., and Massicotte G. (1998). Bidirectional modulation of AMPA receptor properties by exogenous phospholipase A2 in the hippocampus. Hippocampus 8 299-309. 

Coleman R. A., Smith W. L., andNarumiya S. (1994). International Union of Pharmacology classification of prostanoid receptors properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46 205-229. 

Scheuer K., Maras A., Gattaz W. F., Cairns N., Forstl H., and Muller W. E. (1996). Cortical NMDA receptor properties and membrane fluidity are altered in Alzheimer s disease. Dementia. 7 210-214. 

To our surprise, we found that 5 binds anions such as halides or sulfate even in 80% D2O-CD3OD, which is remarkable considering that, despite the large excess of water molecules in these mixtures, the hydrogen-bonding interactions between the anions and the peptide are still efficient [22], Assignment of the structure of the anion complexes of 5 revealed the reason for the unusual receptor properties of this peptide. We could show that 5 preferentially forms 2 1 sandwich-type complexes with suitable anions in which the guests are bound in a cavity located be-... 

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