Cell commitment

Dvorak AM The mouse basophil, a rare and rarely recognized granulocyte. Blood 2000 96 1616-1617. Voehringer D, Shinkai K, Locksley RM Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 2004 20 267-277. 

Edgar I find that idea surprising on the basis of what we see in Drosophila. Have you analysed any other cell lineages where there is a requirement for progression through S phase to get a cell committed ... 

Gu, W., Schneider, J.W., Condorelli, G., Kaushal, S., Mahdavi, V. and Nadal-Ginard, B. (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72, 309-324. 

FIGURE 29-2 Stem cells undergo symmetric divisions to increase the pool size of stem cells, or asymmetric divisions to give rise to a committed progenitor cell and another stem cell. Committed progenitor cells may go on to differentiate immediately to directly replace mature cells lost in response to injury or disease. Alternatively, expansion factors may stimulate extensive division of a specific progenitor cell, and produce large numbers of a mature cell type. 

CSF-1 (also known as macrophage CSF or M-CSF) locally and humorally regulates the survival, proliferation, differentiation and function of mononuclear phagocytic cells (committed progenitor, monoblast, promonocyte, monocyte, tissue... 

Cell commitment. That stage in a cell s life when it becomes committed to a certain line of development. 

This unbalanced growth rapidly leads to cell death if prolonged for more than a generation time (Ruekert and Mueller, 1960). Unbalanced growth will occur in any cells committed to division ( 10.4) yet blocked in one function including those maintained in colcemid for more than a few hours. Moreover, selective blocking of DNA synthesis may have effects which are not apparent until the synchronised cells are released and proceed to the next G1-phase (Firket and Mahieu, 1966 Cress and Gerner, 1977). Schindler et al. 

Once a cell commits to making its antibody, you might think that the antibody would leave the cell so it could patrol the body. But if the contents of all B cells were dumped out into the body, there would be no way to tell which cell the antibody came from. The cell is the factory that makes the particular type of antibody if the antibody finds a bacterium, we need to tell the cell to send us reinforcements. But with this hypothetical setup, we can t get a message back. 

HauCl behave as polyclonal T-cell activators (Figure 3) acting on the early steps of activation and switching on the TCR-dependent signaling pathways aheady es-tabhshed in the cell studied, pathways that are aheady skewed to Th2 cell commitment in BN rats. 

The term erythron has been used to describe collectively the erythropoietic cellular pathway, composed of all cells involved in erythropoiesis, starting with the earliest committed erythroid progenitor and ending with the mature circulating RBC. The earliest cell committed to the erythroid lineage is known as a BFU-E (erythroid). 

The understanding of drug-indnced hematologic disorders requires a basic understanding of hematopoiesis (see Chap. 98 on hematopoiesis). The pluripotential hematopoietic stem cells in the bone marrow, which have the ability to self-reprodnce, maintain the blood. These pluripotential hematopoietic stem cells are further differentiated to intermediate precursor cells, which are also called progenitor cells or colony-forming cells. Committed to a particnlar cell line, these intermediate stem cells differentiate into colonies of each type of blood cell in response to a particular colony-stimulating factor (Fig. 102-1). 

This suggests that cells that are committed to switch can be induced to go to C7l rather than Cy3. But even the detailed analysis of Layton et al. [9] could not distinguish between induction of the specific switch to IgGl and the selection of precursor cells committed to the IgGl isotype, because an identifying marker for the latter cells was missing. In any case, the isotype commitment would have had occurred after activation of the yet uncommitted splenic B cell. 

All cells require trophic factors to prevent apoptosis and thus survive. In the absence of these factors, cells commit suicide. 

Bost F, Caron L, Marchetti I, et al. (2002). Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochem. J. 361 621-627. 

Cell commitment Lineage- commitment Uncommitment Uncommitment... 

Isolation and Phenotypic Characteristics of HSCs. Recent experiments have demonstrated that HSCs in bone marrow from many different species can be purified by FACS as SP cells [40, 45, 46], In 1994, multipotent cells committed to the hematopoietic lineage in mouse according to their different array of cell-surface markers were isolated [39]. This cells were described as KTLS c-kit+ (K), Thy-l.T (a marker on stem cells) (T), (Lineage-marker) (L), and Sca-H(Stem cell... 

Surh, Y. J., More than spice capsaicin in hot chili peppers makes tumor cells commit suicide [comment], J. Natl Cancer Inst, 94, 1263,2002. 

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