Typical antipsychotics

Typical antipsychotic drugs Neuroleptic dtugs conventional antipsychotic diugs older antipsychotic diugs ... 

Clozapine versus typical antipsychotic drugs uncontrolled mirror-image studies. 

Clozapine randomized, controlled trials versus typical antipsychotic drugs. 

TABLE 34-6. First-Generation (Typical) Antipsychotic Dosing of Decanoate Preparations... 

TABLE 34-7. Side Effects of First-Generation (Typical) Antipsychotics... 

Lee, C. et al. (2006). Treatment with olanzapine, risperidone or typical antipsychotic drugs in Asian patients with schizophrenia. Aust. N. Z. J. Psychiatry, 40, 437-45. 

Kaiser etal. (2000) DRD4 (48-bp repeat) Typical antipsychotic drugs, clozapine No association. Schizophrenia Caucasian... 

Joober etal. (1999) HTR2A (T102C) Typical antipsychotic drugs Trend toward association between C/C genotype and poor response among Schizophrenia Caucasian... 

The overall mean chlorpromazine-equivalents per day (CPZe) dose prescribed differed significantly, with lower dosing in Thailand compared with Malaysia and Australia (p < 0.001) (see Table 11.4). Pairwise comparisons revealed that the mean typical antipsychotic dose was significantly higher in Malaysia compared with Thailand (p < 0.001) and NWMH (p < 0.001). There were significant differences observed (p < 0.001) while comparisons of the mean atypical antipsychotic dose showed that Australia was significantly higher compared with Thailand (p < 0.001) and Malaysia (p < 0.001). 

Of the antipsychotic drugs prescribed, 72% were typical antipsychotics, which included haloperidol, chlorpromazine, levomepromazine, sulpiride, trifluoperazine, fluphenazine, flupentixol, and bromperidol. Use of typical drugs was associated with longer hospitalization, male gender, and clinical reports of violence or aggression. Atypical drugs only accounted for 28% of antipsychotic drugs... 

Akathisia The motor restlessness often noted as a side effect of long-term administration of typical antipsychotic drugs. 

Butyrophenones A family of typical antipsychotic drugs (neuroleptics), the most commonly used being haloperidol. 

With the introduction of chlorpromazine in 1952, there was a small revolution in psychiatry patients suffering from psychosis were able to be de-institutionalized. Chlorpromazine and other typical antipsychotics (e.g., haloperidol) demonstrate high in vitro binding affinities for the dopamine D2 receptor (D2). Specifically, their... 

Clozapine is the prototype of atypical antipsychotic drugs, and it has been used effectively to treat patients with schizophrenia who are unresponsive or intolerant to typical antipsychotics [7]. Clozapine is characterized as atypical by its preferential binding to serotonin (5-HT2) and dopamine D4 receptors (D4) relative to dopamine D2 receptors [8]. A recent body of work also suggests that atypicality may be defined by the rate at which clozapine dissociates from D2 receptors. Specifically, clo-... 

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