Muscarinic receptor binding

Kennedy DO, Wake G, Savealev S, Tildesley NTJ, Perry EK, Wake G, Wesnes KA and Scholey AB (2003b). Modulation of mood and cognitive performance following administration of single doses of Melissa officinalis (lemon balm) with human CNS nicotinic and muscarinic receptor binding properties. Neuropsychopharmacology, 28, 1871-1881. 

Schwab BW, Hand H, Costa LG, et al. 1981. Reduced muscarinic receptor binding in tissues of rats tolerant to the insecticide disulfoton. Neurotoxicology 2 635-647. 

Sutin EL, Shiromani PJ, Kelsoe JR Jr, Storch FI, Gillin JC. (1986). Rapid-eye movement sleep and muscarinic receptor binding in rats are augmented during withdrawal from chronic scopolamine treatment. Life Sci. 39(25) 2419-27. 

Acetylcholine acts at two different types of cholinergic receptors [see (1) and (2) in Fig. 2.5]. Muscarinic receptors bind ACh as well as other agonists (muscarine, pilocarpine, bethanechol) and antagonists (atropine, scopolamine). There are at least five different types of muscarinic receptors (M1-M5). All have slow response times. They are coupled to G proteins and a variety of second messenger systems. When activated, the final effect can be to open or close channels for K, Ca ", or CL (Bonner, 1989). Nicotinic receptors are less abundant than the muscarinic type in the CNS. They bind ACh as well as agonists such as nicotine or an-... 

Anticholinergic side effects. Anticholinergic side effects are clinically less significant than would be predicted on the basis of in vitro muscarinic receptor-binding affinity. However, dry mouth may occur. 

Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B. 2000. Decreased muscarinic receptor binding in subjects with schizophrenia A study of the human hippocampal formation. Biol Psychiatry 48 381-388. 

Zavitsanou K, Katsifis A, Yu Y, Huang XF. 2005. M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull 65 ... 

Howard MD, Pope CN. In vitro effects of chlorpyrifos, parathion, methyl parathion and their oxons on cardiac muscarinic receptor binding in neonatal and adult rats. Toxicology 2002 170(1—2) 1—10. 

Naseem SM (1990). Effect of organophosphates on dopamine and muscarinic receptor binding in rat brain Biochem Int, 20, 799-806. 

Katz, L.S. and Marquis, J.K., Modulation of central muscarinic receptor binding in vitro by ultra low levels of the organophosphate paraoxon, Toxicol. Appl. Pharmacol, 101, 114, 1989. 

Viana, G.B., Davis, L.H., and Kauffman, F.C., Effects of organophosphates and nerve growth factor on muscarinic receptor binding number in rat pheochromocytoma PC 12 cells, Toxicol. Appl. Pharmacol, 93, 257, 1988. 

Ehlert, F. Dumont, Y, Roeske, W. R., and Yaniamura, H. 1. (1980). Muscarinic receptor binding in rat brain using the agonist, [" Hlcis iiiethyldioxolane. Life ScL 26,961-967. 

Beianeoun, A. M., and Carr, R. L, (2004). The effect of chlorpyrifos and chlorpyrifo,s-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exptisure. Toxicol. Sci. 77,63-71. 

Van Den Beukel, I., Dijeks, F. A.. Vanderheyden, P, Vauquelin, G and Oortgiesen, M. (1997). Differential muscarinic receptor binding of acetylcholinc.stcra.se inhibitors in rat brain, human brain and Chirtese hamster ovary cells expre.ssing human receptors. J. Pharmacol. Exp. Then 281, 1113-1119. 

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