Qualitative docking

Qualitative results of checklist analyses vary, but generally the analysis produces the answers yes, no, not applicable, or needs more information. The checklist is included in the PrHA report to summarize the noted deficiencies. Understanding these deficiencies leads to sa fety improvement alternatives for consideration, and to identified hazards with suggested actions. I igtires 3.3,1-4 and 3.3.1-5 present checklist analyses of the Dock 8 HF Supply and the Cooling tower chlorination respectively. 

An FMEA is a qualitative, systematic table of equipment, failure modes, and their effects. For each item of equipment, the failure modes and root causes for that failure are identified along with a worst-case estimate of the consequences, the method of detecting the failure and mi "ation ofits effects. Tables 3.3.5-2 and 3.3.5-3 present partial examples ofFMEAs addressing the Cuoling Tower Chlorination System, and the Dock 8 HF Supply System. 

NIRS is useful for the analysis of both raw materials and finished dosage forms. Qualitative determination of pharmaceutical raw materials using NIRS was reported as early as 1982. The largest variations in commercially produced excipients and actives appear to be in moisture content and particle size. These parameters may be monitored by NIRS with relative ease. Incoming substances may be tested for immediate identity confirmation on the receiving dock by inserting a fiber optic probe directly into the barrel. Spectral data for each lot of material purchased may be saved and added to the growing spectral reference library. 

Optical spectra of transferrin C-lobe docked with the transferrin receptor showed a characteristic broad absorption band centred at 465 nm, just as in the receptor-free /zo/o-protein (Figure 2.1 inset). The intensity of this absorbance band declined as more negative potentials were applied in a spectroelectrochemistry experiment, but did not qualitatively change in its overall features. An EPR spectrum of the Fec/TfR complex at pH 5.8, recovered from the OTTLE cell after completion of spectroelectrochemical studies allowed us to conclude that the first coordination shell of Fe " in transferrin is intact and unperturbed when C-lobe is complexed with TfR. Consequently, we assume that C-lobe and Fec/TfR complex have similar if not identical Fe " and Fe binding constants, and so we take for binding of Fe " in the protein-receptor complex to be 10 M as calculated for free Tf. This value was used to correct the observed Nernst plot data by accounting for the dissociation of Fe that occurs upon reduction. Nernst plots for the observed spectroelectrochemical data for FccTf/TfR, and data corrected for Fe dissociation, are presented in Figure 2.7. The corrected plot exhibits typical Nernstian behaviour for a one-electron transfer and a E1/2 value of —285 mV. 

Some studies have been carried out in projects from (Queen s University and these at least provide an initial idea of the problem in Northern Ireland. Taggart (1987), for example, used a simple wet and dry (rainfall gauge t)q)e) collector and a dry collector (microscope slides with double-stick tape) to collect samples from four locations in the Belfast city centre area over a period from June to September 1987. Values for pH ranged from 4.0 to 6.0 and SO4 concentrations ranged from 4.7 to 29.3 ppm. Particles varied from 2 mm to under 100 pm. The highest recorded levels of suspended matter were at Belfast Docks, probably due to local industrial sources. Dry deposition is difficult to estimate quantitatively over short time periods, but qualitative examination showed that fly ash... 

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