Quadrupole time-of-flight hybrid

Leclercq, L. Delatour, C. Hoes, 1. Brunelle, F. Labrique, X. et ah Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification. Rapid Commun Mass Spectrom 2005, 19, 1611-1618. 

Figure 2.5 Quadrupole-time-of-flight hybrid instrument.

In early negative-ion ESI-MS studies, halogenated solvent additives were applied to reduce the risk of discharge formation (Ch. 6.3.2). The use of 1,1,1,3,3,3,-hexafluoro-2-propanol (HFIP) to the mobile phase was proposed for oligonucleotides [22]. This is for instance applied in the rapid characterization of synthetic oligonucleotides by microcapillary LC-MS on a quadrupole-time-of-flight hybrid (Q-TOF) instrument [20]. 

Chapter 23 Hybrid Quadrupole Time-of-Flight (Q/TOF) Instruments... 

The instrumental analysis for the identification of UV filters degradation products formed during the fungal treatment process was performed by means of HPLC coupled to tandem mass spectrometry using a hybrid quadrupole-time-of-flight mass spectrometer (HPLC-QqTOF-MS/MS). Chromatographic separation was achieved on a Hibar Purospher STAR HR R-18 ec. (50 mm x 2.0 mm, 5 pm, from Merck). In the optimized method, the mobile phase consisted of a mixture of HPLC grade water and acetonitrile, both with 0.15% formic acid. The injection volume was set to 10 pL and the mobile phase flow-rate to 0.3 mL/min. 

Ehlers, M. Schmidt, S. Lee, B.J. Grote-meyer, J. Design and Set-Up of an External Ion Source Coupled to a Quadrupole-lon-Trap Reflectron-Time-of-Flight Hybrid Instram t. Eur. J. Mass Spectrom. 2000, 6, 377-385. 

New instrumentation for the analysis of the proteome has been developed including a MALDI hybrid quadrupole time of flight instrument which combines advantages of the mass finger printing and peptide sequencing methods for protein identification (Andersen and Mann 2000). 

The most common types of MS/MS instruments available to researchers in food chemistry include triple quadrupole mass spectrometers and ion traps. Less common but commercially produced tandem mass spectrometers include magnetic sector instruments, Fourier transform ion cyclotron resonance (FTICR) mass spectrometers, and quadrupole time-of-flight (QTOF) hybrid instruments (Table A.3A.1). Beginning in 2001, TOF-TOF tandem mass spectrometers became available from instrument manufacturers. These instruments have the potential to deliver high-resolution tandem mass spectra with high speed and should be compatible with the chip-based chromatography systems now under development. 

Wrona, M., Timo, M., Bateman, K. P., Mortishire-Smith, R. J., and O Connor, D. (2005). All-in-one analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid... 

Serum Modified Blight and Dyer extraction Micro HPLC (Ci 8) MS ESI hybrid quadrupole time of flight 58 (36)... 

Many instrumental set-ups and geometries have been explored. In triple quadrupole mass spectrometry, the first quadrupole selects the parent ion of interest, the second works as a collision cell to fragment the parent ion, and the third isolates the proper product ion. A hybrid type is the quadrupole time-of-flight (Q-TOF) instrument. 

Boyd, R.K., Tandem mass spectrometry quadropole and hybrid instruments, Metftodi nzymo/. 193, 154-200, 1990 Jonscher, K.R. and Yates, J.R., 111, The quadrupole ion trap mass spectrometry — a small solution to a big challenge. Anal. Biochem. 244, 1-15, 1997 Chemushevich, I.V., Loboda, A.V., and Thomson, B.A., An introduction to quadrupole-time-of-flight mass spectrometry, J. Mass Spectrom. 36, 849-865, 2001 Ens, W. and Standing, K.G., Hybrid quadrapole/time-of-flight mass spectrometers for analysis of biomolecules. Methods Enzymol. 402,49-78, 2005 Payne, A.H. and GUsh, G.L., Tandem mass spectrometry in quadrupole ion trap and ion cyclotron resonance mass spectrometers. Methods Enzymol. 402, 109-148, 2005. 

Mass analyzers differ in sensitivity, accuracy, and resolution. Among others, they include quadrupole, triple quadrupole (TQ), ion trap, linear ion trap, time of flight, Eourier transform ion cyclotron resonance, and hybrid combinations such as quadrupole-time of flight (Q-TOE) analyzers. 

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