Quadriceps Femoris

Figure 2. Force generation and energy metabolism in human quadriceps femoris muscle stimulated intermittently at 20 Hz, with 1.6 sec tetani with 1.6 sec rest periods between tetani. The upper panel shows force, ATP turnover rate, and pH the middle panel, the concentrations of PCr, P and lactate and the lower panel, ATP, ADP, IMP, H, and calculated H2PO4. From Hultman et al. (1990), with permission from Human Kinetics Publishers.

Harris, R.C., Sahlin, K., Hultman. E. (1977). Phosphagen and lactate contents of m. quadriceps femoris of man after exercise. J. Appl. Physiol. 43. 852-857. 

Protein metabolism Cortisol promotes the breakdown of proteins and inhibits protein synthesis. This leads to muscle wasting in the quadriceps-femoris groups, and muscular activities may become difficult as a result. The effect of cortisol is opposite to that of insulin. 

Intramuscular injections. Generally, intramuscular injections are made with small gauge needles into the epaxial muscles on either side of the lumbar vertebral column or the quadriceps femoris muscle on the ventral side of either rear leg. Due to the small size of mice, very small volumes (e.g., 0.05 mL) should be injected. 

The test is preferably conducted by injections into the M. sacrospialis on the dorsum or into the M. vastus lateralis on the femur of the rabbits. Alternatively, in the rat the injections can be performed into the M. quadriceps femoris. Also dogs could be used, however for animal wellfare reasons, smaller animals are preferred. Injection of the vehicle is performed on the contra-lateral side of the animal. The injection volume should be 1 ml for smaller animals and 2 ml for the dog. 

The time course of use and replenishment of creatine is shown in the study of exercising human subjects reported in Figure 4.36, The subjects exercised on a stationary bicycle that was adjusted so that exhaustion would be reached after 6 minules. Muscle biopsies, taken before and after exercise, from the quadriceps femoris muscle of the leg were used for analysis of cneatine-P The data demonstrate that the reservoir of creatine-P, substantially depleted by the end of the exercise period, was rapidly repleted during the subsequent resting period. 

FrCiURE 4.36 Creiitine phosphate concern rations before and after OKencise. Human subjects exercised on a stationary bJeycIc, adjusted SO that exhaustion was reached after 6 min. Muscle biopsies, taken from the quadriceps femoris muscle of the leg, were used for analyses of creatine phosphate. (Redrawn with permission from Harris ct u/., 1976.)... 

Repeated intramuscular injections into the thighs of newborns and infants can cause severe and widespread muscular contractures of the quadriceps femoris (SEDA-8, 560). In some cases, penicillin was implicated. 

Konishi Y, Fukubayashi T and Takeshita D. Possible mechanism of quadriceps femoris weakness in patients with ruptured anterior cruciate ligament. Med Sci Sports Exerc. 2002 34 1414-1418. 

Mase Jr., V.J., Hsu, J.R., Wolf, S.E., Wenke, J.C., Baer, D.G., Owens, J., Badylak, S.F., Walters, T.J., 2010. Clinical application of an acellular biologic scaffold for surgical repair of a large, traumatic quadriceps femoris muscle defect. Orthopedics 33, 511. 

To determine the effects of GA on different tissues, the following tissues were examined, namely, liver (L), kidney (K), visceral and subcutaneous adipose tissues (VAT and SAT), quadriceps femoris (QF), and abdominal muscles (AM). 

Lewek, M., Rudolph, K. Snyder-Mackler, L. 2004. Quadriceps femoris musde weakness and activation failure in patients with symptomatic knee osteoarthritis. J. Orthop. Res. 22 110 115. 

The quadriceps femoris consists of four muscles of the anterior thigh. These knee extensor muscles are, perhaps, the most significant. Weakened quadriceps muscles decrease the stability of the knee and make it more prone to injury. 

Kinugasa R, Watanabe T, Ijima H et al. (2006) Effects of vascular occlusion on maximal force, exercise-induced T2 changes, and BMG activities of quadriceps femoris muscles. Int J Sports Med 27, 511-516. 

In the lower limbs the quadriceps femoris muscles are most severely affected and undergo progressive atrophy, particularly of the vastus medialis and lateralis, with relative sparing of the rectus femoris (Figure 9.2). As in the upper limbs the weakness is often more severe on the nondominant side. Weakness of the ankle dorsiflexors is also common but severe foot-drop occurs infrequently. Other muscle groups such as the hip extensors and abductors and ankle plantar flexors are usually only mildly affected. 

Slowly progressive muscle weakness and atrophy selective pattern with quadriceps femoris and finger flexors affected first, followed by other muscle groups frequently asymmetric and more severe on nondominant side... 

Figure 4 Neuromusclar stimulation of the quadriceps femoris muscles.

Jakobsson P, Jordfelt I, Henriksson J. Metabolic eirzyme activity in the quadriceps femoris muscle in patients with severe COPD. Am J Respir Crit Care Med 1995 151 374-377. 

Selkowitz DM. Improvement in isometric strength of the quadriceps femoris muscle after training with electrical stimulation. Phys Ther 1985 65 186-196. 

Lewek M, Stevens J, Snyder-Mackler L. The use of electrical stimulation to increase quadriceps femoris muscle force in an elderly patient following a total knee arthroplasty. Phys Ther 2001 81(9) 1565-1571. 

The anterior compartment of the thigh includes the sartorius and the quadriceps femoris muscle. Addi-... 

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