Foot-drop

The alimentary symptoms may be overshadowed by neuromuscular dysfunction, accompanied by signs of motor weakness that may progress to paralysis of the exterior muscles or the wrist (wrist drop), and less often, of the ankles (foot drop). Encephalopathy, the most serious result of lead poisoning, frequendy occurs in children as a result of pica, ie, ingestion of inorganic lead compounds in paint chips this rarely occurs in adults. Nephropathy has also been associated with chronic lead poisoning (147). The toxic effects of lead may be most pronounced on the developing fetus. Consequendy, women must be particulady cautious of lead exposure (148). The U.S. Center for Disease Control recommends a blood level of less than 10 p.m per 100 mL for children. 

USP (Oncovin) vindesine sulfate [59917-39 ] C43H55N5O7 -H2S0 852.01 (50) chil-dren lymphocytic leukemia Hodgkin s disease non-Hodg-kin s lymphomas Wilm s tumor neuroblastoma rhabdomyosarcoma, investigational dmg (paresthesias, foot drop, double vision, etc) constipation ileus alopecia leu-kopenia (occasional) ... 

One of the earliest effects on the nervous system is found in damage to the nerve supply of the hands and feet. Muscle weakness at the wrist and ankle, in fact, may be one of the first things other than the general unwellness that draws the attention of the victim to his/her condition. It occurs as a dragging of the foot (foot drop) or loss of ability to hold the wrist in the horizontal or raised position (wrist drop). There may also be shaking and trembling, and ultimately full paralysis. 

A number of cases of subacute sensory motor polyneuropathy have been described among sterilizing workers exposed to ethylene oxide. Findings have included weakness with bilateral foot drop, sensory loss, loss of reflexes, and neuropathologic changes on EMG in the lower extremities. In some cases, sural nerve biopsy showed axonal degeneration. Removal from exposure resulted in resolution of symptoms in 1-7 months. The abnormalities have... 

Adult nervous system effects are also apparent following lead exposure. In the past, painters using lead-based paint developed damage to the peripheral nervous system, which caused a wrist or foot drop. Nerve damage can be evaluated in the... 

K) One-Hundred Foot Drop Test. The test is similar to "Forty-Foot Drop Test (described as Test No 103 in MIL-STD-331 and here as item f, under Physical Testing of Fuzes) and is used in some studies when it is considered that the 40-foot drop test is not severe enough (p IIB-33 of Ref 39)... 

Military Standard. "Fuze and Fuze Components, Environmental and Performance Tests for MIL-STD-331 (1966 1967) Class 100. Laboratory Tests - Jolt (101) Jumble (102) Forty-Foot Drop (103) Transportation Vibration (104) Temperature Humidity (105) Vacuum Steam Pressure (106) Salt Spray (Fog) (107) Waterproofness (108) Rain Test (Exposed Fuze Storage) (109) Fungus Resistance (110) Five-Foot Drop (111) Extreme Temperature Storage (112) Thermal Shock (113) Rough Handling (Packaged)... 

Five-Foot Drop Test. One of the field tests to check the safety and operability of a... 

Forty-foot Drop Test. A complete description of the procedure is given as test No... 

Five-Foot Drop Test 111 is briefly described in Vol 4, p D1093-R... 

Foot drop -ethanol actnntyagamst [DISINFECTANTS AND ANTISEPTICS] (Vol 8) - [LEADCOMPOUNDS - LEAD SALTS] (Vol 15)... 

Two chemists investigating the insecticidal properties of Mipafox developed weakness and unsteady gait about two to three weeks after their recovery from an acute poisoning episode. This progressed to bilateral foot drop in one victim, who ultimately did recover. The other was less fortunate, progressing to a persistent and flaccid paralysis of his lower extremities, with no improvement after two years (ref. 167). 

Ohio Edison Company Toronto, ON 2 testa 1990 Whole tires 4> to 20X atu content tires burned down to residual natal within 18-foot drop to boiler bed Teat In Nay 1990 tlrea dropped In at S different rotes equating to 0, 5, 10, IS, and 20 percent tlrea as fuel. All particulate and SO] Units were net. Pulverized coal-fed, front-fired, wet botton, noncontlnuous tap. Tires dropped Into boiler. Ohio EPA and USEPA have approved permits allowing tire Input up to a 20X atu level. References 2, 10, 11, 12, and 13... 

Pure TOCP is a colorless liquid (fp, -27°C bp, 410°C). It produces pronounced neurological effects and causes degeneration of the neurons in the body s central and peripheral nervous systems, although fatalities are rare. Early symptoms of TOCP poisoning include nausea, vomiting, and diarrhea, accompanied by severe abdominal pain. Normally a 1- to 3-week latent period occurs after these symptoms have subsided, followed by manifestations of peripheral paralysis, as evidenced by wrist drop and foot drop. In some cases, the slow recovery is complete, whereas in others partial paralysis remains. 

There have been sporadic reports of bilateral foot-drop with peroneal nerve involvement (65). A major neuropathy, with high stepping gait and inability to dorsiflex the foot, occurred in an 84-year-old woman this presumed adverse effect remitted 8 weeks after withdrawal (66). 

Forty-foot Drop Test. A complete description of the procedure is given as test No 103 of MIL-STD-331. See Vol 4, p D1093-R, Test f3... 

As the disease progresses, the ankle jerk reflex is lost, and the muscular weakness spreads upward, involving first the extensor muscles of the foot, then the muscles of the caff, and finally the extensors and flexors of the thigh. At fins stage, there is pronounced toe and foot drop - the patient is unahle to keep either the toe or the whole foot extended off the ground. When the arms are affected, there is a similar inahUity to keep the hand extended - wrist drop. 

There appeared to be considerable variability in the response to the TOCP, with some victims suffering paralysis and even death after only one drink of the contaminated jake. Most of the victims suffered paralysis for a long time, some permanently, and required crutches or sticks to walk, which they did with a shuffling gait, in some cases dragging their feet ( foot drop ). This became popularly known as Jake leg , and the way victims walked became known as the jake walk . 

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