Purine receptors

Amino acid receptors Monoamine receptors Lipid receptors Purine receptors Neuropeptide receptors Peptide hormone receptors Chemokine receptors Glycoprotein receptors Protease receptors Metabotropic glutamate and GABAb receptors Adrenoceptors, dopamine and 5-HT receptors, muscarinic and histamine receptors Prostaglandin, thromboxane and PAF receptors Adenosine and ATP (P2Y) receptors Neuropeptide Y, opiate, cholecystokinin VIP, etc. Angiotensin, bradykinin, glucagon, calcitonin, parathyroid, etc. Interleukin-8 TSH, LH/FSH, chorionic gonadotropin, etc. Thrombin... 

PKC is central to TRPVl regulation, inasmuch that it couples an array of receptors to TRPVl. Some examples have been discussed above. Other notable examples include the chemokine receptor CCRl [54], the metabotropic purine receptor P2Y [55] and the prostaglandin receptors EPl and IP [56]. 

Hirst That is an example. There is no doubt that some transmitters get to arterioles, but it is equally not clear to me that in a mesenteric arteriole noradrenaline accesses the a receptors. ATP might access purine receptors and trigger voltage-dependent Ca2+ entry, but we have been told that CICR doesn t necessarily occur there. It is not clear that this pathway is used. It is, however, used to modulate depolarization. 

D. Satchell (1984). Purine receptors classification and properties. Trends Pharmacol. Sci. 5 340-343. 

A3 receptors. These are also known collectively as purine PI receptors. There are two other classes of purine receptors, P2X and P2Y, which are thought to be involved in nociception and especially visceral pain. The ligand for these receptors is ATP. The A1 receptor is coupled to the inhibitory Gi protein and the A2 receptor to the stimulatory Gs protein, and respectively inhibit or activate adenylyl cyclase, while the A3 receptor mediates G protein-dependent activation of phospholipase C. 

Brown DA, Pilippov AK, Branard EA (2000) Inhibition of potassium and calcium currents in neurons by molecularly-defined P2Y receptors. J Auton Nerv Sys 81 31-6 Brown SJ, James S, Reddington M et al (1990) Both Ai and A2a purine receptors regulate striatal acetylcholine release. J Neurochem 55 31-8... 

Patent 4-Quinolinemethanol Derivatives as Purine Receptor Antagonists... 

Purine receptors Adenosine, AMP, ADP and ATP can act extracellularly as hormones or transmitters, too In particular, adenosine receptors that occur in the heart, the brain, and the lung are the targets of theophylline and caffeine. Adenosine itself is being used for the treatment of a special type of cardiac arrhythmia. 

Metabotropic glutamate receptors (11 subt5 es) Purine receptors (P2Y) Adenosine, AMP, ADP, ATP Peptide hormone receptors... 

TheophylUne increases the dose of adenosine needed for conversion of supraventricular tachycardia, through competitive inhibition at purine receptors (46). 

ADENOSINE RECEPTOR AGONISTS act extra-cellularly at receptors variously known as adenosine receptors, PI purine receptors, PI receptors, P purinoceptors, or nucleoside receptors. Adenosine receptors have a wide range of mainly inhibitory actions in the body, including cardiac slowing, a fall in blood pressure, dilation of bloqd vessels, inhibition of platelet aggregation, inhibition of intestinal movements and actions within the central nervous system. 

Ap4A (Ap(4)A Pi,Ps-diadenosine tetraphosphate) is an endogenous agent used in synthetic form as a pharmacological tool in purine receptor classification studies. It is a PURINE p2 RECEPTOR AGONIST, particularly active at the pyrimidine-preferring receptor subtypes. Ap(4)A Ap4A. 

PURINE P2 RECEPTOR ANTAGONISTS P2 receptors (P2-purinoceptors) are quite distinct from PI receptors (see ADENOSINE RECEPTORS), with the former activated by nucleotides, typically ATP and the latter by nucleosides, typically adenosine see purine receptor agonists. As a result of coupling considerations and structural information derived from cloning and expression studies, the P2 purinoceptors are now divided into two main classes. 

Psychotomimetic drugs biochemistry and pharmacology. 7. 165 Purine receptors and their pharmacological roles, 18. 292 The Rate of contemporary drug discovery. 8. I Recent /3-adrenoreceptor stimulants. 5. 197... 

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